Table 1 Aspects of initiating second-line Multiple Sclerosis treatment that makes the information exchange complex

Multiple Sclerosis-related aspects

• Chronic disease

• Unpredictable course

• Potentially physically disabling disease

• Affects cognitive functions

Drug-related aspects

• Available drugs differ in efficacy

• Available drugs differ in risk/adverse effect profile

• Available drugs differ in administration form

• Long-term effects still unknown

Individual-related aspects

• Variability in the response to treatments

• Variability in drug tolerance

• Variability in health literacy

• Variability in understanding of risk