Table 2 Prevalence of events assumed in each trial, according to the scenario and to the application data set, and weight and maximal rates of misclassifications assigned to each event to build the decision rule

Simulation study

All scenarios

Prevalence in FD arm

0.39

0.15

0.06

0.04

Scenario A

Prevalence in HD arm

0.39

0.15

0.06

0.04

Good decision ^[3]

Acc

Acc

Acc

Acc

Scenario B

Prevalence in HD arm

0.26

0.10

0.04

0.03

Good decision ^[3]

Acc

Acc

Acc

Acc

Scenario C

Prevalence in HD arm

0.58

0.23

0.09

0.06

Good decision ^[3]

U

U

Acc

Acc

Scenario D

Prevalence in HD arm

0.78

0.30

0.12

0.08

Good decision ^[3]

U

U

U

U

Scenario E

Prevalence in HD arm

1.00

0.45

0.18

0.12

Good decision ^[3]

U

U

U

U

Weight^[4]

100

88

70

60

Maximal misclassifications rates

Class a misclassifications ^[5]

0.10

0.10

0.10

0.10

Class b misclassifications ^[6]

0.10

0.16

0.25

0.30

Data set for application

Prevalence in FD arm

0.39

0.15

0.06

0.04

Prevalence in HD arm

0.47

0.23

0.12

0.08

Good decision ^[3]

U

U

U

U