Parameters | Value in simulation | Statistical notation in the linear predictor used for simulation of datasetb |
---|---|---|
Varying-parameters | ||
Number of trials | 6, 10, 16, 20, 26, 30, 40, 50 | – |
Magnitude of the interaction effecta | 0, −0.01 | beta.inter |
Between-trial variance of the interaction effecta | 0, 0.005, 0.05, 0.5 | V 2 |
Fixed-parameters | ||
Number of patients included in each trial | between 30 and 199 patients in small trials, and 200 and 400 patients in large trials | j |
Ratio of small to large trials | 1:1 | – |
Number of trial arms | 2 | treat |
Ratio of randomization | 1:1 | – |
Magnitude of the treatment effecta | −1 | beta.treat |
Between-trial variance of the treatment effecta | 0.063 | V 1 |
Effect of age on the outcome | 0.05 | age |
Random intercept variance | 0.25 | σ 2 |
Random slope variance | 0.04 | τ 2 |
Correlation between random intercept and random slope variances | 0.8 | ρ |
Age of individual patients | N(mean. age, variance. age) | age |
Mean age of patients within trials | N(67,20.25) | mean. age |
Variance of age within trials | N(49, 1) | variance. age |