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Table 5 Bias in the interaction effect between treatment effect and covariate (age) in each of the models in the presence of high but plausible heterogeneity in the interaction effect

From: A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials

No. of trials Model 1 Model 2 Model 3 Model 4 Model 5 Model 6 Model 7
6 0.00179 (0.09149) −0.00006 (0.09595) 0.00323 (0.10316) 0.00179 (0.09149) 0.00038 (0.09622) 0.00323 (0.10316) −0.06454 (1.87747)
10 −0.00101 (0.07082) −0.00079 (0.07411) − 0.00070 (0.08183) − 0.00101 (0.07082) − 0.00072 (0.07410) −0.00070 (0.08183) 0.01286 (1.22375)
16 −0.00013 (0.05543) −0.00060 (0.05795) − 0.00094 (0.06589) −0.00014 (0.05543) − 0.00050 (0.05800) −0.00094 (0.06589) 0.01857 (0.93068)
20 −0.00049 (0.05012) −0.00102 (0.05260) − 0.00119 (0.05889) −0.00049 (0.05012) − 0.00097 (0.05254) −0.00119 (0.05889) − 0.02249 (0.81903)
26 −0.00051 (0.04289) − 0.00079 (0.04524) 0.00012 (0.05107) − 0.00051 (0.04289) −0.00076 (0.04517) 0.00012 (0.05107) −0.01126 (0.67902)
30 −0.00013 (0.04099) 0.00051 (0.04331) 0.00018 (0.04889) −0.00013 (0.04099) 0.00049 (0.04323) 0.00018 (0.04889) 0.00940 (0.62751)
40 0.00034 (0.03480) 0.00073 (0.03687) 0.00050 (0.04180) 0.00034 (0.03480) 0.00074 (0.03686) 0.00050 (0.04180) 0.01953 (0.55119)
50 −0.00010 (0.03198) −0.00005 (0.03364) − 0.00013 (0.03806) −0.00010 (0.03198) − 0.00004 (0.03368) −0.00013 (0.03806) 0.00074 (0.48328)
  1. Values in brackets are Monte Carlo standard errors