Table 6 Observed coverage of the interaction effect between treatment effect and covariate (age) in each of the models, with a nominal coverage of 95% in the presence of high but plausible heterogeneity in the interaction effect
No. of trials | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | Model 6 | Model 7 |
|---|---|---|---|---|---|---|---|
6 | 0.89400 (0.00688) | 0.88500 (0.00713) | 0.83850 (0.00823) | 0.89450 (0.00687) | 0.88550 (0.00712) | 0.83850 (0.00823) | 0.94350 (0.00516) |
10 | 0.92250 (0.00598) | 0.92100 (0.00603) | 0.88950 (0.00701) | 0.92250 (0.00598) | 0.92150 (0.00601) | 0.88950 (0.00701) | 0.95250 (0.00476) |
16 | 0.92850 (0.00576) | 0.92600 (0.00585) | 0.90800 (0.00646) | 0.92900 (0.00574) | 0.92700 (0.00582) | 0.90800 (0.00646) | 0.94900 (0.00492) |
20 | 0.93350 (0.00557) | 0.93900 (0.00535) | 0.92350 (0.00594) | 0.93400 (0.00555) | 0.93450 (0.00553) | 0.92350 (0.00594) | 0.94050 (0.00529) |
26 | 0.94150 (0.00525) | 0.94300 (0.00518) | 0.93250 (0.00561) | 0.94150 (0.00525) | 0.94250 (0.00521) | 0.93250 (0.00561) | 0.95300 (0.00473) |
30 | 0.93150 (0.00565) | 0.93300 (0.00559) | 0.91750 (0.00615) | 0.93150 (0.00565) | 0.93400 (0.00555) | 0.91750 (0.00615) | 0.94900 (0.00492) |
40 | 0.94650 (0.00503) | 0.93800 (0.00539) | 0.93250 (0.00561) | 0.94650 (0.00503) | 0.93700 (0.00543) | 0.93250 (0.00561) | 0.94450 (0.00512) |
50 | 0.94700 (0.00501) | 0.94950 (0.00490) | 0.93400 (0.00555) | 0.94700 (0.00501) | 0.94900 (0.00492) | 0.93400 (0.00555) | 0.95400 (0.00468) |