Fig. 1

Evidence Network Comparing Biologics for Moderate to Severe Rheumatoid Arthritis, ACR50 Response. Treatment nodes are sized to proportionally reflect the numbers of patients randomized to each intervention, while the line thickness of edges joining nodes are asized to propotionally reflect the numbers of studies informing each comparison. Legend: ABA = abatacept; ADA = adalimumab; BAR_4 = 4 mg baricitinib; CERTO = certolizumab pegol; csDMARD = conventional synthetic disease-modifying anti-rheumatic drug; ETN = etanercept; GOL = golimumab; INF = infliximab; IV = intravenous; MTX = methotrexate; RIT = rituximab; SAR_200 = 200 mg sarilumab; SC = subcutaneous; SSZ = sulfasalazine; STD = standard dose; TOC_4 = tocilizumab 4 mg/kg; TOC_8 = 8 mg/kg tocilizumab; TOF = tofacitinib