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Table 2 Full data estimate of cure at day 28 follow-up using the Kaplan-Meier method and cured proportion

From: Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

TreatmentEstimate95% Confidence IntervalSESE†
Full data K-M a
Full data cured proportion b
  1. AL artemether-lumefantrine , ASAQ artesunate-amodiaquine , DP dihydroartemisinin-piperaquine , SE standard error
  2. † Standard error after complementary log-log transformation. The cloglog transformation was applied as the MI estimates were computed on complementary log-log scale for the application of Rubin’s combination rules to be valid.
  3. a For the derivation of the K-M estimates, new infections were considered as censored on the day of recurrence
  4. bThe estimates of cured proportion (total cured/total number of patients treated) was computed by considering those with new infections as cured. The variance for cured proportion (\( \hat{p} \)) for a total number of patients (n) was calculated as \( \hat{p}\left(1-\hat{p}\right)/n \). The variance was converted to the cloglog scale using the delta method presented in Additional file 1, Section C. The 95% confidence interval was derived using Wilson’s method using binom.confint routine in binom package R.