Treatment | Estimate | 95% Confidence Interval | SE | SE†|
|---|
Full data K-M a |
 AL | 0.960 | 0.948—0.972 | 0.0061 | 0.1559 |
 ASAQ | 0.979 | 0.969—0.989 | 0.0049 | 0.2367 |
 DP | 0.983 | 0.977—0.990 | 0.0035 | 0.2082 |
Full data cured proportion b |
 AL | 0.964 | 0.951—0.973 | 0.0056 | 0.1562 |
 ASAQ | 0.980 | 0.968—0.987 | 0.0047 | 0.2357 |
 DP | 0.984 | 0.975—0.989 | 0.0034 | 0.2132 |
- AL artemether-lumefantrine , ASAQ artesunate-amodiaquine , DP dihydroartemisinin-piperaquine , SE standard error
- †Standard error after complementary log-log transformation. The cloglog transformation was applied as the MI estimates were computed on complementary log-log scale for the application of Rubin’s combination rules to be valid.
- a For the derivation of the K-M estimates, new infections were considered as censored on the day of recurrence
- bThe estimates of cured proportion (total cured/total number of patients treated) was computed by considering those with new infections as cured. The variance for cured proportion (\( \hat{p} \)) for a total number of patients (n) was calculated as \( \hat{p}\left(1-\hat{p}\right)/n \). The variance was converted to the cloglog scale using the delta method presented in Additional file 1, Section C. The 95% confidence interval was derived using Wilson’s method using binom.confint routine in binom package R.
