Table 3 Results of the association parameter α obtained from the baseline Cox model, the TVCM and the joint model fitted to data generated considering the linear marker trajectory (scenario 2 of Table 1) with α∈(0,0.3,0.6) and σε∈(0.1,0.3,0.5) with CV ∈(3.1%,9.4%,15.6%). Mean of the maximum likelihood estimates (Est), asymptotic standard error (ASE), bias, percentage bias (%Bias) and 95% coverage probabilities (CP) are shown
α=0 | α=0.3 | α=0.6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
σε | Model | Est | ASE | Bias | CP | Est | ASE | %Bias | CP | Est | ASE | %Bias | CP |
Cox.baseline | 0.000 | 0.060 | 0.000 | 95 | 0.254 | 0.056 | -15 | 86 | 0.545 | 0.059 | -9.2 | 83 | |
0.1 | TVCM(1x/week) | -0.003 | 0.060 | -0.003 | 96 | 0.293 | 0.058 | -2.3 | 95 | 0.582 | 0.061 | -3.0 | 93 |
TVCM(4x/week) | -0.001 | 0.060 | -0.001 | 95 | 0.298 | 0.059 | -0.7 | 94 | 0.594 | 0.062 | -1.0 | 94 | |
joint model | -0.003 | 0.059 | -0.003 | 96 | 0.301 | 0.058 | 0.3 | 95 | 0.604 | 0.061 | 0.7 | 94 | |
Cox.baseline | 0.000 | 0.058 | 0.000 | 96 | 0.240 | 0.054 | -20 | 79 | 0.508 | 0.057 | -15 | 62 | |
0.3 | TVCM(1x/week) | -0.003 | 0.058 | -0.003 | 96 | 0.275 | 0.057 | -8.3 | 92 | 0.541 | 0.059 | -9.8 | 83 |
TVCM(4x/week) | -0.001 | 0.058 | -0.001 | 95 | 0.279 | 0.057 | -7.0 | 92 | 0.550 | 0.059 | -8.3 | 86 | |
joint model | -0.003 | 0.060 | -0.003 | 95 | 0.301 | 0.059 | 0.3 | 95 | 0.604 | 0.064 | 0.7 | 94 | |
Cox.baseline | 0.000 | 0.055 | 0.000 | 96 | 0.216 | 0.051 | -28 | 61 | 0.449 | 0.053 | -25 | 23 | |
0.5 | TVCM(1x/week) | -0.003 | 0.055 | -0.003 | 96 | 0.244 | 0.053 | -19 | 80 | 0.474 | 0.055 | -21 | 35 |
TVCM(4x/week) | -0.002 | 0.055 | -0.002 | 95 | 0.247 | 0.054 | -18 | 84 | 0.480 | 0.055 | -20 | 40 | |
joint model | -0.004 | 0.062 | -0.004 | 95 | 0.301 | 0.062 | 0.3 | 95 | 0.606 | 0.069 | 1.0 | 94 | |