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Table 7 Estimates of the association of PTX3, and log(PTX3), with time to GvHD from the baseline Cox model, TVCM and joint model

From: Joint model robustness compared with the time-varying covariate Cox model to evaluate the association between a longitudinal marker and a time-to-event endpoint

 

PTX3

log(PTX3)

Model

Est

SE

HR

95% HR CI

Est

SE

HR

95% HR CI

Cox.baseline

-0.08

0.04

0.92

(0.85,1.00)

-0.17

0.14

0.84

(0.64, 1.11)

TVCM

0.13

0.03

1.14

(1.08,1.20)

0.60

0.14

1.82

(1.38, 2.41)

joint-constant

0.05

0.08

1.05

(0.95,1.21)

-0.28

0.29

0.76

(0.42, 1.36)

joint-Weibull

0.11

0.01

1.11

(0.84,1.47)

0.79

0.49

2.20

(0.84,5.78)

joint-spline

0.13

0.12

1.14

(0.90,1.44)

1.13

0.55

3.11

(1.05, 9.18)

  1. The estimated association between PTX3 and GvHD (Est), the standard error of the estimate (SE), the hazard ratio (HR), and the 95% confidence interval of the HR (95% HR CI) are reported