Privacy-protecting estimation of adjusted risk ratios using modified Poisson regression in multi-center studies

Table 2 Point Estimates and Standard Errors Using the Summary-Level Modified Poisson Method and Pooled Individual-Level Data Analysis: Analysis of Real-World Data

Covariates	Summary-Level Modified Poisson Method		Pooled Individual-Level Data Analysis
Covariates	Parameter Estimates	Standard Errors	Parameter Estimates	Standard Errors
Intercept	−1.5653147	0.1040146	−1.5653147	0.1040146
Exposure^a	−0.4632219	0.0422368	−0.4632219	0.0422368
Demographics
Age (years)	0.0029253	0.0018694	0.0029253	0.0018694
Female sex	0.0860355	0.0478638	0.0860355	0.0478638
Combined comorbidity score	0.0543412	0.0125169	0.0543412	0.0125169
Diagnosis of
Asthma	−0.0212109	0.0538624	−0.0212109	0.0538624
Atrial fibrillation	0.0835820	0.1249359	0.0835820	0.1249359
Atrial flutter	0.1638268	0.2598721	0.1638268	0.2598721
Coronary artery disease	0.1597157	0.0746721	0.1597157	0.0746721
Deep vein thrombosis	0.1738365	0.1371837	0.1738365	0.1371837
Gastroesophageal reflux disease	−0.0586971	0.0393428	−0.0586971	0.0393428
Hypertension	0.0046885	0.0448018	0.0046885	0.0448018
Ischemic stroke	−0.1592596	0.1986055	−0.1592596	0.1986055
Myocardial infarction	0.2069423	0.1509918	0.2069423	0.1509918
Pulmonary embolism	0.2846648	0.1436404	0.2846648	0.1436404
Sleep apnea	−0.0261550	0.0396516	−0.0261550	0.0396516
Use of
Anticoagulants	0.1064905	0.1205252	0.1064905	0.1205252
Assistive walking device	0.0908909	0.1394227	0.0908909	0.1394227
Home oxygen	0.0732620	0.1162295	0.0732620	0.1162295
Number of drug dispensing
Unique drug classes	−0.0579458	0.0166577	−0.0579458	0.0166577
Unique generic medications	0.0673783	0.0136406	0.0673783	0.0136406

ISSN: 1471-2288