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Table 2 Point Estimates and Standard Errors Using the Summary-Level Modified Poisson Method and Pooled Individual-Level Data Analysis: Analysis of Real-World Data

From: Privacy-protecting estimation of adjusted risk ratios using modified Poisson regression in multi-center studies

Covariates

Summary-Level Modified Poisson Method

Pooled Individual-Level Data Analysis

Parameter Estimates

Standard Errors

Parameter Estimates

Standard Errors

Intercept

−1.5653147

0.1040146

−1.5653147

0.1040146

Exposurea

−0.4632219

0.0422368

−0.4632219

0.0422368

Demographics

 Age (years)

0.0029253

0.0018694

0.0029253

0.0018694

 Female sex

0.0860355

0.0478638

0.0860355

0.0478638

Combined comorbidity score

0.0543412

0.0125169

0.0543412

0.0125169

Diagnosis of

 Asthma

−0.0212109

0.0538624

−0.0212109

0.0538624

 Atrial fibrillation

0.0835820

0.1249359

0.0835820

0.1249359

 Atrial flutter

0.1638268

0.2598721

0.1638268

0.2598721

 Coronary artery disease

0.1597157

0.0746721

0.1597157

0.0746721

 Deep vein thrombosis

0.1738365

0.1371837

0.1738365

0.1371837

 Gastroesophageal reflux disease

−0.0586971

0.0393428

−0.0586971

0.0393428

 Hypertension

0.0046885

0.0448018

0.0046885

0.0448018

 Ischemic stroke

−0.1592596

0.1986055

−0.1592596

0.1986055

 Myocardial infarction

0.2069423

0.1509918

0.2069423

0.1509918

 Pulmonary embolism

0.2846648

0.1436404

0.2846648

0.1436404

 Sleep apnea

−0.0261550

0.0396516

−0.0261550

0.0396516

Use of

 Anticoagulants

0.1064905

0.1205252

0.1064905

0.1205252

 Assistive walking device

0.0908909

0.1394227

0.0908909

0.1394227

 Home oxygen

0.0732620

0.1162295

0.0732620

0.1162295

Number of drug dispensing

 Unique drug classes

−0.0579458

0.0166577

−0.0579458

0.0166577

 Unique generic medications

0.0673783

0.0136406

0.0673783

0.0136406

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