Skip to main content

Table 3 Number of stratification and minimization covariates with a statistically significant difference across cells in 250 simulations

From: Simulation and minimization: technical advances for factorial experiments designed to optimize clinical interventions

  Number of SCs with statistically significant differences Ave. % of SCs Number of MCs with statistically significant differences Ave. % of MCs
0 1 2 0 1 2 3 4 5 6
SR 92.4% 7.2% 0.4% 8.0% 67.6% 27.6% 4.8% 0.0% 0.0% 0.0% 0.0% 37.2%
SPB 99.6% 0.0% 0.4% 0.8% 72.4% 24.4% 3.2% 0.0% 0.0% 0.0% 0.0% 30.8%
MTI2 91.2% 7.2% 1.6% 10.4% 68.4% 24.4% 7.2% 0.0% 0.0% 0.0% 0.0% 38.8%
MTI3 92.0% 6.4% 1.6% 9.6% 66.4% 24.8% 8.0% 0.8% 0.0% 0.0% 0.0% 43.2%
MSB 95.6% 4.0% 0.4% 4.8% 69.2% 26.0% 3.6% 0.8% 0.4% 0.0% 0.0% 37.2%
Min. 100.0% 0.0% 0.0% 0.0% 100.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
  1. Note. SR = simple randomization; SPB = stratification with permuted blocks; MTI = maximum tolerated imbalance; MSB = minimal sufficient balance; Min. = minimization; SC = stratification covariate; MC = minimization covariate