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Table 4 Sensitivity analysis for diagnostic performance (95% confidence intervals) compared to Medicare referent standards

From: Assembling and validating a heart failure-free cohort from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study

A. With addition of self-reported symptoms (orthopnea and/or paroxysmal nocturnal dyspnea)
  HF according to Medicare
N (%)
Excluded from HF-free cohort
N
Included in HF-free cohort
N
NPV %PPV %Sens %Spec %
Hospitalization for HF+293 (2.9%)2563799.5% (99.3–99.7%)9.5% (8.4–10.6%)87.4% (83.6–91.2%)75.1% (74.2–75.9%)
9766 (97.1%)24367330
Principal diagnosis of HF+968 (9.6%)74622297.0% (96.6–97.4%)27.7% (26.0–29.4%)77.1% (74.4–79.7%)78.6% (77.8–79.4%)
9091 (90.4%)19467145
Any diagnosis of HF+1135 (11.3%)83829796.0% (95.5–96.4%)31.1% (29.4–32.9%)73.8% (71.3–76.4%)79.2% (78.4–80.1%)
8924 (88.7%)18547070
B. With addition of adjudicated heart failure
  HF according to Medicare
N (%)
Excluded from HF-free cohort
N
Included in HF-free cohort
N
NPV %PPV %Sens %Spec %
Hospitalization for HF+293 (2.9%)2365799.3% (99.2–99.5%)14.6% (12.9–16.4%)80.5% (76.0–85.1%)85.9% (85.2–86.6%)
9766 (97.1%)13758391
Principal diagnosis of HF+968 (9.6%)65731196.3% (95.9–96.7%)40.8% (38.4–43.2%)67.9% (64.9–70.8%)89.5% (88.9–90.1%)
9091 (90.4%)9548137
Any diagnosis of HF+1135 (11.3%)72441195.1% (94.7–95.6%)44.9% (42.5–47.4%)63.8% (61.0–66.6%)90.1% (89.4–90.7%)
8924 (88.7%)8878037