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Table 2 Association between explanatory variables and improvement of ADHD

From: Individualizing the dosage of Methylphenidate in children with attention deficit hyperactivity disorder

 

Univariable Analysis

Multivariable Analysis

Fixed effects

Covariates

OR (95% CI)

P-Value

OR (95% CI)

P-Value

Sex (Male)

0.8358 (0.5684, 1.2289)

0.361

–

–

Age (month)

0.9991 (0.9829, 1.0053)

0.795

–

–

Weight (kg)

1.0270 (1.0084, 1.0459)

0.004*

–

–

Birthweight (kg)

0.8265 (0.6149, 1.1109)

0.212

–

–

Time interval (month)

1.0844 (1.0677, 1.1014)

<  0.001*

1.0833 (1.0661,1.1007)

<  0.001*

Severity a

0.9597 (0.9462, 0.9734)

<  0.001*

0.9500 (0.9305,0.9699)

<  0.001*

Log Dose MPH, (mg per kg)

2.2766 (1.6855,3.0750)

<  0.001*

2.3653 (1.6602,3.3699)

<  0.001*

Taking risperidone

0.9035 (0.6720, 1.2150)

0.503

–

–

Taking Fluoxetine

0.7398 (0.4524, 1.2097)

0.227

–

–

ODD

0.6842 (0.4648, 1.0070)

0.064

–

–

Mood disorder b

0.6846 (0.2952,1.5873)

0.379

–

–

Anxiety disorder c

1.9619 (0.7667,1.5672)

0.614

–

–

Other comorbidities d

0.9692 (0.8631,1.0883)

0.587

–

–

Random intercept

–

Variance estimation

(95% CI)

–

1.452

(1.2931, 1.6108)

  1. a The OR and its CI is computed for the centered value(i.e. severity- 51.3817). b Mood Disorder is the combination of Mood and bipolar disorders. c Anxiety disorder is a combination of GAD, SAD, OCD, Phobia, and Anxiety disorder. d Other comorbidities are included MR, LD, stutter, Tic, and MDD. *Significant at 0.05