Table 3 Definitions of the immune cell traits
| Â | Cell surface and intracellular markers |
|---|---|
Pro-inflammatory cells | Â |
T helper type 1 (Th1) cells | CD4+IFN+ (expressed as a % of CD4+ cells) |
T helper type 17 (Th17) cells | CD4+IL17+ (expressed as a % of CD4+ cells) |
Activated CD4+ cells | CD4+CD38+ (expressed as a % of CD4+ cells) |
Activated CD8+ cells | CD8+CD38+ (expressed as a % of CD8+ cells) |
Natural Killer (NK) cells | CD3-CD56+CD16+ (expressed as a % of lymphocytes) |
Gamma delta T cells | CD3+ γδTCR+ (expressed as a % of CD3+ cells) |
Classic Monocytes | CD14++CD16- (expressed as a % of monocytes) |
Pro-fibrotic cells | Â |
T helper type 2 (Th2) cells | CD4+IL4+ (expressed as a % of CD4+ cells) |
Non-classic Monocytes | CD14+CD16++ (expressed as a % of monocytes) |
Anti-inflammatory and anti-fibrotic cells | Â |
T regulatory cells (T-reg) | CD4+CD25+CD127- (expressed as a % of CD4+ cells) |
Intermediate Monocytes | CD14+CD16+ (expressed as a % of monocytes) |
Pro-inflammatory cells that mark chronic use of adaptive immunity | Â |
Naive CD4+ cells | CD4+CD45RA+ (expressed as a % of CD4+ cells) |
Naive CD8+ cells | CD8+CD45RA+ (expressed as a % of CD8+ cells) |
Senescent CD4+ cells | CD4+CD28- (expressed as a % of CD4+ cells) |
Senescent CD8+ cells | CD8+CD28- (expressed as a % of CD8+ cells) |
CD4+ memory cells | CD4+CD45RO+ (expressed as a % of CD4+ cells) |
CD8+ memory cells | CD8+CD45RO+ (expressed as a % of CD8+ cells) |