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Table 4 Personal factors and mean willingness-to-participate scores

From: Factors associated with patient willingness to participate in anaesthesia clinical trials: a vignette-based cross-sectional study

Personal factors influencing the willingness to participateStrongly agreedAgreedIndifferentDisagreedStrongly disagreedP value*
I could receive better treatment. N (%)65 (18.5%)182 (51.9%)52 (14.8%)34 (9.7%)18 (5.1%) 
Mean score ± SD69.6 ± 19.060.9 ± 17.658.7 ± 18.356.8 ± 21.350.7 ± 24.5< 0.001
I could help other patients. N (%)110 (32.5%)179 (52.8%)33 (9.7%)13 (3.8%)4 (1.2%) 
Mean score ± SD67.8 ± 17.460.3 ± 17.952.5 ± 21.344.9 ± 19.440.6 ± 18.8< 0.001
I could contribute to medical progress. N (%)147 (42.0%)172 (49.1%)23 (6.6%)6 (1.7%)2 (0.6%) 
Mean score ± SD68.9 ± 16.357.4 ± 18.351.4 ± 22.045.8 ± 19.733.3 ± 11.8< 0.001
I would be considered a “guinea pig.” N (%)34 (9.8%)100 (28.9%)100 (28.9%)55 (15.9%)57 (16.5%) 
Mean score ± SD50.1 ± 24.156.4 ± 18.063.7 ± 16.962.5 ± 15.470.5 ± 20.3< 0.001
I trust doctors. N (%)83 (23.2%)204 (57.0%)40 (11.2%)25 (7.0%)6 (1.7%) 
Mean score ± SD68.2 ± 18.460.7 ± 17.054.7 ± 17.151.7 ± 23.841.0 ± 28.6< 0.001
I am afraid of adverse events related to the drug tested. N (%)82 (23.3%)155 (44.0%)52 (14.8%)47 (13.4%)16 (4.6%) 
Mean score ± SD48.5 ± 20.858.2 ± 16.770.1 ± 16.569.8 ± 14.772.6 ± 26.9< 0.001
I could receive a more effective treatment. N (%)62 (18.7%)159 (47.9%)57 (17.2%)42 (12.7%)12 (3.6%) 
Mean score ± SD70.1 ± 16.962.7 ± 16.156.9 ± 20.253.8 ± 18.554.5 ± 29.8< 0.001
I would respect my personal convictions. N (%)84 (25.5%)126 (38.3%)100 (30.4%)12 (3.7%)7 (2.1%) 
Mean score ± SD65.6 ± 18.962.8 ± 15.759.5 ± 19.949.7 ± 19.246.4 ± 28.4< 0.001
I would be anxious about surgery. N (%)60 (17.0%)130 (36.8%)68 (19.3%)63 (17.9%)32 (9.1%) 
Mean score ± SD52.4 ± 24.156.7 ± 18.064.2 ± 16.864.1 ± 14.976.5 ± 18.0< 0.001
I would be worried about inefficacy of the drug tested. N (%)48 (14.1%)119 (35.0%)73 (21.5%)76 (22.4%)24 (7.1%) 
Mean score ± SD47.9 ± 25.357.2 ± 16.661.6 ± 16.566.8 ± 18.180.5 ± 17.3< 0.001
I think that research only benefits the doctor’s career. N (%)12 (3.5%)29 (8.3%)38 (10.9%)125 (35.9%)144 (41.4%) 
Mean score ± SD38.9 ± 29.055.7 ± 14.857.0 ± 12.959.3 ± 17.765.9 ± 19.5< 0.001
  1. *Cuzick test for trend