Skip to main content

Table 5 Study-related factors and mean willingness-to-participate scores

From: Factors associated with patient willingness to participate in anaesthesia clinical trials: a vignette-based cross-sectional study

Study-related factors influencing the willingness to participateStrongly agreedAgreedNo opinionDisagreedStrongly disagreedP value*
If you received financial compensation, would you be more willing to participate? N (%)55 (14.9%)62 (16.8%)70 (18.9%)73 (19.7%)110 (29.7%) 
Mean score ± SD65.5 ± 17.662.2 ± 15.863.1 ± 16.256.2 ± 18.857.3 ± 23.60.006
If participating in the study required commuting to the hospital, would you decline to participate? N (%)40 (11.1%)79 (21.9%)57 (15.8%)111 (30.8%)74 (20.5%) 
Mean score ± SD48.3 ± 25.256.6 ± 17.360.8 ± 17.862.3 ± 15.569.1 ± 19.6< 0.001
If the study required blood tests, would you decline to participate? N (%)24 (6.4%)46 (12.3%)52 (13.9%)110 (29.4%)142 (38.0%) 
Mean score ± SD44.3 ± 21.555.5 ± 17.755.4 ± 19.258.6 ± 15.168.2 ± 19.1< 0.001
If the study required randomly assigned treatment, would you decline to participate? N (%)95 (27.1%)110 (31.4%)42 (12.0%)76 (21.7%)27 (7.7%) 
Mean score ± SD50.4 ± 22.658.6 ± 15.264.4 ± 16.466.1 ± 16.469.1 ± 24.4< 0.001
If the study required a treatment that was prescribed by the study and not by your doctor, would you be willing to participate? N (%)37 (10.4%)143 (40.1%)39 (10.9%)84 (23.5%)54 (15.1%) 
Mean score ± SD71.1 ± 21.664.9 ± 13.359.5 ± 15.554.4 ± 19.348.4 ± 26.5< 0.001
If the study involved a placebo (inactive substance), would you decline to participate? N (%)40 (11.3%)62 (17.5%)65 (18.3%)101 (28.5%)87 (24.5%) 
Mean score ± SD43.2 ± 27.856.7 ± 18.060.6 ± 17.361.2 ± 15.968.5 ± 17.2< 0.001
Many clinical trials are double-blind studies. This means that neither doctors nor the participants are aware which participants receive the test drug and which receive the placebo. Would you consider this a reason to decline participation? N (%)62 (17.5%)95 (26.8%)34 (9.6%)82 (23.2%)81 (22.9%) 
Mean score ± SD48.5 ± 23.854.5 ± 16.664.9 ± 12.264.8 ± 16.070.4 ± 19.1< 0.001
  1. *Cuzick test for trend