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Table 5 Study-related factors and mean willingness-to-participate scores

From: Factors associated with patient willingness to participate in anaesthesia clinical trials: a vignette-based cross-sectional study

Study-related factors influencing the willingness to participate

Strongly agreed

Agreed

No opinion

Disagreed

Strongly disagreed

P value*

If you received financial compensation, would you be more willing to participate? N (%)

55 (14.9%)

62 (16.8%)

70 (18.9%)

73 (19.7%)

110 (29.7%)

 

Mean score ± SD

65.5 ± 17.6

62.2 ± 15.8

63.1 ± 16.2

56.2 ± 18.8

57.3 ± 23.6

0.006

If participating in the study required commuting to the hospital, would you decline to participate? N (%)

40 (11.1%)

79 (21.9%)

57 (15.8%)

111 (30.8%)

74 (20.5%)

 

Mean score ± SD

48.3 ± 25.2

56.6 ± 17.3

60.8 ± 17.8

62.3 ± 15.5

69.1 ± 19.6

< 0.001

If the study required blood tests, would you decline to participate? N (%)

24 (6.4%)

46 (12.3%)

52 (13.9%)

110 (29.4%)

142 (38.0%)

 

Mean score ± SD

44.3 ± 21.5

55.5 ± 17.7

55.4 ± 19.2

58.6 ± 15.1

68.2 ± 19.1

< 0.001

If the study required randomly assigned treatment, would you decline to participate? N (%)

95 (27.1%)

110 (31.4%)

42 (12.0%)

76 (21.7%)

27 (7.7%)

 

Mean score ± SD

50.4 ± 22.6

58.6 ± 15.2

64.4 ± 16.4

66.1 ± 16.4

69.1 ± 24.4

< 0.001

If the study required a treatment that was prescribed by the study and not by your doctor, would you be willing to participate? N (%)

37 (10.4%)

143 (40.1%)

39 (10.9%)

84 (23.5%)

54 (15.1%)

 

Mean score ± SD

71.1 ± 21.6

64.9 ± 13.3

59.5 ± 15.5

54.4 ± 19.3

48.4 ± 26.5

< 0.001

If the study involved a placebo (inactive substance), would you decline to participate? N (%)

40 (11.3%)

62 (17.5%)

65 (18.3%)

101 (28.5%)

87 (24.5%)

 

Mean score ± SD

43.2 ± 27.8

56.7 ± 18.0

60.6 ± 17.3

61.2 ± 15.9

68.5 ± 17.2

< 0.001

Many clinical trials are double-blind studies. This means that neither doctors nor the participants are aware which participants receive the test drug and which receive the placebo. Would you consider this a reason to decline participation? N (%)

62 (17.5%)

95 (26.8%)

34 (9.6%)

82 (23.2%)

81 (22.9%)

 

Mean score ± SD

48.5 ± 23.8

54.5 ± 16.6

64.9 ± 12.2

64.8 ± 16.0

70.4 ± 19.1

< 0.001

  1. *Cuzick test for trend