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Table 1 Results of individual-based modelling of worked example of external comorbidity

From: Adjusting for comorbidity in incidence-based DALY calculations: an individual-based modeling approach

Disease [− health state]Adjusted YLD/1000 cases
(95% UI)
Unadjusted YLD/1000 cases
(95% UI)
Overestimation of YLD
(95% UI)
Difference in YLD/1000 cases
Colorectal cancer (All health states)471.7 (447.8–496.8)473.3 (449.2–498.9)0.3%1.6
Diagnosis/therapy only309.4 (291.8–329.9)310.5 (292.8–331.1)0.4%1.1
Pre-terminal/ terminal only163.5 (147.4–178.7)164.0 (148.0–179.2)0.3%0.5
HAP co-existent with colorectal cancer (All health states)73.0 (51.4–98.1)75.3 (52.8–102.0)3.0%2.3
Symptomatic infection0.4 (0.3–0.5)0.4 (0.3–0.5)9.9%0.0
Severe sepsis, septic shock1.1 (0.8–1.5)1.4 (0.9–1.9)25.5%0.3
PTSD17.4 (8.1–28.8)18.1 (8.4–29.8)3.9%0.7
Cognitive impairment14.4 (8.7–21.1)14.8 (8.9–21.7)3.0%0.4
Physical impairment36.2 (28.0–45.4)36.7 (28.4–46.0)1.4%0.5
Renal failure & renal replacement therapy4.2 (0–13.8)4.5 (0–4.5)7.9%0.3
  1. Note. Results compare Years Lived with Disability (YLD) per 1000 cases for colorectal cancer adjusted and unadjusted for comorbidity due to healthcare-associated pneumonia (HAP), and also HAP (among patients with colorectal cancer), both adjusted and unadjusted for comorbidity, in terms of absolute and relative differences in YLD
  2. PTSD post-traumatic stress disorder, UI uncertainty interval