Skip to main content

Table 1 Results of individual-based modelling of worked example of external comorbidity

From: Adjusting for comorbidity in incidence-based DALY calculations: an individual-based modeling approach

Disease [− health state]

Adjusted YLD/1000 cases

(95% UI)

Unadjusted YLD/1000 cases

(95% UI)

Overestimation of YLD

(95% UI)

Difference in YLD/1000 cases

Colorectal cancer (All health states)

471.7 (447.8–496.8)

473.3 (449.2–498.9)

0.3%

1.6

Diagnosis/therapy only

309.4 (291.8–329.9)

310.5 (292.8–331.1)

0.4%

1.1

Pre-terminal/ terminal only

163.5 (147.4–178.7)

164.0 (148.0–179.2)

0.3%

0.5

HAP co-existent with colorectal cancer (All health states)

73.0 (51.4–98.1)

75.3 (52.8–102.0)

3.0%

2.3

Symptomatic infection

0.4 (0.3–0.5)

0.4 (0.3–0.5)

9.9%

0.0

Severe sepsis, septic shock

1.1 (0.8–1.5)

1.4 (0.9–1.9)

25.5%

0.3

PTSD

17.4 (8.1–28.8)

18.1 (8.4–29.8)

3.9%

0.7

Cognitive impairment

14.4 (8.7–21.1)

14.8 (8.9–21.7)

3.0%

0.4

Physical impairment

36.2 (28.0–45.4)

36.7 (28.4–46.0)

1.4%

0.5

Renal failure & renal replacement therapy

4.2 (0–13.8)

4.5 (0–4.5)

7.9%

0.3

  1. Note. Results compare Years Lived with Disability (YLD) per 1000 cases for colorectal cancer adjusted and unadjusted for comorbidity due to healthcare-associated pneumonia (HAP), and also HAP (among patients with colorectal cancer), both adjusted and unadjusted for comorbidity, in terms of absolute and relative differences in YLD
  2. PTSD post-traumatic stress disorder, UI uncertainty interval