Table 1 Examples of clinical trials designed using the TiTE-CRM

Ben-Josef et al. [8]

Radiation delivered with gemcitabine in participants with unresectable pancreatic cancer

Brown et al. [9]

Concurrent temozolomide and intensity modulated radiation therapy in glioblastoma multiforme

Chugh et al. [10]

Doxorubicin plus cixutumumab in soft tissue sarcoma

Frangou et al. [11]

Radiotherapy, chemotherapy, and M6620 in participants with oesophageal cancer (CHARIOT)

Kim et al. [12]

Whole brain radiotherapy and RRx-001 in radioresistant melanoma brain metastases

Kyriakopoulos et al. [13]

APC-100 in male participants with castrate-resistant prostate cancer

Haan et al. [14]

Three trials of radical radiotherapy and Olaparib in non-small cell lung cancer, breast cancer, and head and neck squamous cell carcinoma

Lao et al. [15]

Bortezomib administered in combination with whole brain radiotherapy in participants with brain metastasis

Lepeak et al. [16]

Continuous MKC-1 in participants with advanced or metastatic solid malignancies

Muler et al. [17]

Cisplatin combined with gemcitabine and radiation therapy in pancreatic cancer

Schneider et al. [18]

Vorinostat in combination with docetaxel in participants with advanced and relapsed solid malignancies

Tevaarwerk et al. [19]

Continuous MKC-1 in participants with advanced or metastatic solid malignancies

Zhen et al. [20]

Cabozantinib and gemcitabine in participants with advanced pancreatic ductal adenocarcinoma