From: Optimal, minimax and admissible two-stage design for phase II oncology clinical trials
p0 | p1 | α | β | αT | 1-βT | n1 | r1 | PETS1 | n | r | ENS | Type | q |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.05 | 0.25 | 0.05 | 0.20 | 0.047 | 0.812 | 9 | 0 | 0.630 | 17 | 2 | 12.0 | Optimal | [0.000, 0.643] |
0.043 | 0.801 | 12 | 0 | 0.540 | 16 | 2 | 13.8 | Minimax | [0.643, 1.000] | ||||
0.10 | 0.30 | 0.05 | 0.20 | 0.047 | 0.805 | 10 | 1 | 0.736 | 29 | 5 | 15.0 | Optimal | [0.000, 0.286] |
0.040 | 0.806 | 11 | 1 | 0.697 | 27 | 5 | 15.8 | Admissible | [0.286, 0.500] | ||||
0.036 | 0.805 | 12 | 1 | 0.659 | 26 | 5 | 16.8 | Admissible | [0.500, 0.730] | ||||
0.033 | 0.802 | 15 | 1 | 0.549 | 25 | 5 | 19.5 | Minimax | [0.730, 1.000] | ||||
0.30 | 0.50 | 0.05 | 0.20 | 0.050 | 0.803 | 15 | 5 | 0.722 | 46 | 18 | 23.6 | Optimal | [0.000, 0.216] |
0.044 | 0.801 | 18 | 6 | 0.722 | 42 | 17 | 24.7 | Admissible | [0.216, 0.250] | ||||
0.046 | 0.804 | 19 | 6 | 0.666 | 39 | 16 | 25.7 | Minimax | [0.250, 1.000] | ||||
0.05 | 0.25 | 0.10 | 0.10 | 0.093 | 0.903 | 9 | 0 | 0.630 | 24 | 2 | 14.6 | Optimal | [0.000, 0.091] |
0.083 | 0.905 | 10 | 0 | 0.599 | 22 | 2 | 14.8 | Admissible | [0.091, 0.333] | ||||
0.078 | 0.905 | 11 | 0 | 0.569 | 21 | 2 | 15.3 | Admissible | [0.333, 0.524] | ||||
0.074 | 0.903 | 13 | 0 | 0.513 | 20 | 2 | 16.4 | Minimax | [0.524, 1.000] | ||||
0.10 | 0.30 | 0.10 | 0.10 | 0.098 | 0.901 | 12 | 1 | 0.659 | 35 | 5 | 19.8 | Optimal | [0.000, 0.032] |
0.10 | 0.904 | 18 | 2 | 0.734 | 26 | 4 | 20.1 | Admissible | [0.032, 0.231] | ||||
0.095 | 0.903 | 16 | 1 | 0.515 | 25 | 4 | 20.4 | Minimax | [0.231, 1.000] | ||||
0.30 | 0.50 | 0.10 | 0.10 | 0.097 | 0.905 | 22 | 7 | 0.671 | 46 | 17 | 29.9 | Optimal | [0.000, 0.111] |
0.090 | 0.901 | 21 | 6 | 0.551 | 42 | 16 | 30.4 | Admissible | [0.111, 0.605] | ||||
0.094 | 0.900 | 28 | 7 | 0.365 | 39 | 15 | 35.0 | Minimax | [0.605, 1.000] | ||||
0.05 | 0.25 | 0.05 | 0.10 | 0.049 | 0.902 | 9 | 0 | 0.630 | 30 | 3 | 16.8 | Optimal | [0.000, 0.167] |
0.047 | 0.913 | 10 | 0 | 0.599 | 29 | 3 | 17.6 | Inadmissible | – | ||||
0.043 | 0.906 | 10 | 0 | 0.599 | 28 | 3 | 17.2 | Admissible | [0.167, 0.375] | ||||
0.040 | 0.908 | 11 | 0 | 0.569 | 27 | 3 | 18.0 | Inadmissible | – | ||||
0.037 | 0.905 | 12 | 0 | 0.540 | 26 | 3 | 18.4 | Admissible | [0.375, 0.667] | ||||
0.034 | 0.901 | 15 | 0 | 0.463 | 25 | 3 | 20.4 | Minimax | [0.667, 1.000] | ||||
0.10 | 0.30 | 0.05 | 0.10 | 0.047 | 0.902 | 18 | 2 | 0.734 | 35 | 6 | 22.5 | Optimal | [0.000, 0.474] |
0.044 | 0.901 | 19 | 2 | 0.705 | 34 | 6 | 23.4 | Admissible | [0.474, 0.737] | ||||
0.041 | 0.902 | 22 | 2 | 0.620 | 33 | 6 | 26.2 | Minimax | [0.737, 1.000] | ||||
0.30 | 0.50 | 0.05 | 0.10 | 0.050 | 0.903 | 24 | 8 | 0.725 | 63 | 24 | 34.7 | Optimal | [0.000, 0.114] |
0.044 | 0.902 | 22 | 7 | 0.671 | 62 | 24 | 35.2 | Inadmissible | – | ||||
0.045 | 0.902 | 20 | 6 | 0.608 | 59 | 23 | 35.3 | Inadmissible | – | ||||
0.046 | 0.903 | 23 | 7 | 0.618 | 56 | 22 | 35.6 | Admissible | [0.114, 0.250] | ||||
0.047 | 0.902 | 24 | 7 | 0.565 | 53 | 21 | 36.6 | Minimax | [0.250, 1.000] |