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Table 3 Meta-analysis of the association of the PPARγ rs1801282 polymorphism and NSAID use with the risk of cancer

From: Advanced stratification analyses in molecular association meta-analysis: methodology and application

Meta-analysis

No. of studies

Genetic comparison

Non-NSAID users

NSAID users

Ph

Model

OR

95%CI

POR

Ph

Model

OR

95%CI

POR

Nagao M et al., 2014

6

CC

NA

 

1 (reference)

 

NA

NA

 

1 (reference)

 

NA

CG + GG

0.865

F

0.932

0.830-1.046

0.865

0.034

R

0.942

0.724-1.226

 

0.658

 

CC

CG + GG

Non-NSAID user

NA

 

1 (reference)

 

NA

NA

 

1 (reference)

 

NA

NSAID user

0.942

F

0.743

0.673-0.820

0

0.065

F

0.786

0.663-0.932

 

0.006

  1. Note: OR odds ratio, CI confidence interval; F fixed-effect model; NA not available, NSAID nonsteroidal anti-inflammatory drug, PPARγ peroxisome proliferator-activated receptor gamma