Table 4 Meta-analysis of the MDM2 rs2279744 polymorphism in lung cancer by smoking status
From: Advanced stratification analyses in molecular association meta-analysis: methodology and application
Meta-analysis | No. of studies | Sources of results | Genetic comparison | Non-smokers | Smokers | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
I2 | Model | OR | 95%CI | P | I2 | Model | OR | 95%CI | P | ||||||
He W et al., 2012 [3] | 5 | A | TG vs. TT | 28.60% | F | 1.275 | 1.066-1.526 | 0.008 | 72.40% | R | 1.015 | 0.816-1.262 | 0.896 | ||
GG vs. TT | 0.00% | F | 1.583 | 1.257-1.994 | < 0.001 | 84.00% | R | 1.201 | 0.816-1.768 | 0.353 | |||||
GG + TG vs. TT | 40.50% | F | 1.334 | 1.125-1.581 | 0.001 | 83.2%a | R | 1.072 | 0.823-1.394 | 0.607 | |||||
Non-smokers | Smokers | ||||||||||||||
I2 | Model | OR | 95%CI | I2 | Model | OR | 95%CI | ||||||||
B | TG vs. TT | – | 1.271 | 1.063-1.521 | – | 1.013 | 0.846-1.212 | ||||||||
GG vs. TT | – | 1.521 | 1.214-1.905 | 1.200 | 0.886-1.625 | ||||||||||
GG + TG vs. TT | 40.50% | F | 1.328 | 1.119-1.575 | – | NA | NA | ||||||||