Fig. 3From: Comparison of four algorithms on establishing continuous reference intervals for pediatric analytes with age-dependent trendSimulation of time frames with different sample sizes (n) and mean difference between adjacent time frames (m). a. Simulation of time frames with different sample sizes (n), n = sample size in time frame. b. Simulation of mean difference between adjacent time frames, m = mean difference between adjacent time frames. ALP, alkaline phosphatase. Notes: Lines are fitted by cubic splinesBack to article page