Table 2 Estimated posterior median difference (and 95% credible intervals) in change from baseline for urinary incontinence, voiding and urgency episodes obtained from multivariate network meta-analysis
From: Multivariate network meta-analysis incorporating class effects
Treatment | Code | Incontinence episodes†| Voiding episodes†| Urgency episodes†|
|---|---|---|---|---|
Sacral nerve stimulation | (81) | -7.43 (-9.59,-4.73) | -7.64 (-9.82,-4.91) | -7.96 (-10.19,-5.29) |
OnaBoNT-A 200u trigone sparing | (73) | -2.38 (-3.13,-1.66) | -2.61 (-3.38,-1.9) | -2.9 (-3.76,-2.14) |
Estradiol 3mg intravaginally | (128) | -1.91 (-3.6,-0.26) | -2.13 (-3.82,-0.51) | -2.44 (-4.18,-0.72) |
Oxybutynin IR 2.5mg b.i.d + Salivary pastilles | (98) | -1.84 (-3.51,-0.17) | -2.06 (-3.73,-0.35) | -2.39 (-4.09,-0.7) |
OnaBoNT-A 100u bladder base + trigone | (79) | -1.73 (-3.26,-0.12) | -1.95 (-3.48,-0.35) | -2.25 (-3.84,-0.62) |
Electrostimulation + PFE + Bladder training | (97) | -1.6 (-2.52,-0.7) | -1.8 (-2.77,-0.91) | -2.13 (-3.05,-1.16) |
Solifenacin/trospium + placebo injection | (100) | -1.64 (-2.56,-0.59) | -1.85 (-2.82,-0.8) | -2.14 (-3.17,-1.12) |
OnaBoNTA 100u trigone sparing | (72) | -1.58 (-1.96,-1.21) | -1.69 (-2.04,-1.36) | -2.06 (-2.53,-1.64) |
OnaBoNT-A 100u bladder body + trigone | (78) | -1.48 (-2.43,-0.48) | -1.7 (-2.67,-0.69) | -2.01 (-3.02,-1.05) |
Oxybutynin intravesically 5mg t.i.d | (14) | -1.31 (-2.4,-0.07) | -1.53 (-2.63,-0.28) | -1.84 (-2.95,-0.54) |
Tolerodine ER 4mg q.d + Neurostimulation | (96) | -1.35 (-1.76,-0.96) | -1.6 (-2.05,-1.15) | -1.9 (-2.43,-1.38) |
Propiverine 30mg b.i.d | (42) | -1.3 (-3.48,0.7) | -1.53 (-3.69,0.47) | -1.87 (-4.06,0.26) |
Estriol 1mg intravesival | (131) | -1.31 (-2.53,0.05) | -1.54 (-2.72,-0.19) | -1.85 (-3.11,-0.45) |
Oxybutynin ER 10mg q.d | (8) | -1.06 (-1.53,-0.56) | -1.29 (-1.8,-0.78) | -1.59 (-2.18,-0.99) |
Mirabegron 100mg b.i.d | (48) | -1.05 (-1.69,-0.43) | -1.26 (-1.9,-0.64) | -1.58 (-2.29,-0.83) |
Solifenacin ER 10mg q.d | (30) | -0.87 (-1.09,-0.65) | -1.13 (-1.35,-0.92) | -1.41 (-1.78,-1.04) |
Imidafenacin IR 0.25mg b.i.d | (37) | -0.88 (-1.49,-0.32) | -1.11 (-1.72,-0.53) | -1.42 (-2.06,-0.75) |
Mirabegron 150mg b.i.d | (49) | -0.83 (-1.69,-0.08) | -1.07 (-1.92,-0.32) | -1.37 (-2.29,-0.58) |
Pregabalin 150mg b.i.d + Tolterodine ER 4mg q.d | (102) | -0.83 (-1.57,-0.2) | -1.06 (-1.78,-0.45) | -1.36 (-2.15,-0.67) |
Oxybutynin IR 3mg t.i.d | (19) | -0.83 (-1.17,-0.47) | -1.02 (-1.4,-0.64) | -1.35 (-1.81,-0.88) |
Tolterodine ER 4mg q.d + Behaviour therapy | (87) | -0.78 (-1.47,-0.15) | -1 (-1.71,-0.35) | -1.32 (-2.03,-0.62) |
Propiverine ER 30mg q.d | (42) | -0.76 (-1.27,-0.26) | -0.99 (-1.54,-0.43) | -1.3 (-1.92,-0.7) |
Darifenacin ER 30mg q.d | (38) | -0.73 (-1.35,-0.13) | -0.95 (-1.59,-0.33) | -1.26 (-1.9,-0.57) |
Tolterodine ER 2mg b.i.d + Oestrogen 0.625mg 2xwk | (99) | -0.72 (-1.22,-0.22) | -0.94 (-1.5,-0.38) | -1.26 (-1.88,-0.66) |
Fesoterodine ER 8mg q.d | (26) | -0.71 (-0.9,-0.53) | -0.94 (-1.14,-0.76) | -1.26 (-1.62,-0.9) |
Trospium IR 15mg t.i.d + Physiotherapy | (91) | -0.7 (-1.54,0.14) | -0.95 (-1.8,-0.1) | -1.24 (-2.11,-0.39) |
Solifenacin ER (5mg-10mg) q.d | (31) | -0.67 (-0.91,-0.43) | -0.85 (-1.09,-0.61) | -1.18 (-1.56,-0.78) |
Solabegron 125mg b.i.d | (55) | -0.64 (-0.92,-0.38) | -0.87 (-1.16,-0.61) | -1.18 (-1.58,-0.78) |
Mirabegron 25mg q.d | (50) | -0.63 (-0.9,-0.36) | -0.85 (-1.12,-0.57) | -1.14 (-1.54,-0.74) |
Oxybutynin vaginal ring 6mg q.d | (17) | -0.61 (-1.16,-0.03) | -0.86 (-1.41,-0.27) | -1.15 (-1.78,-0.53) |
Solifenacin ER 5mg - 15mg q.d | (34) | -0.61 (-1.11,-0.12) | -0.82 (-1.38,-0.29) | -1.12 (-1.75,-0.54) |
Trospium ER 60mg q.d | (44) | -0.6 (-0.94,-0.24) | -0.81 (-1.15,-0.45) | -1.12 (-1.58,-0.66) |
Cizolirtine Citrate 400mg b.i.d | (57) | -0.58 (-1.21,-0.04) | -0.83 (-1.47,-0.24) | -1.14 (-1.81,-0.47) |
Mirabegron 100mg q.d | (52) | -0.59 (-0.79,-0.4) | -0.78 (-0.97,-0.57) | -1.1 (-1.45,-0.75) |
Solifenacin ER 5mg q.d | (29) | -0.57 (-0.79,-0.38) | -0.73 (-0.93,-0.56) | -1.09 (-1.46,-0.73) |
Mirabegron 50mg q.d | (51) | -0.56 (-0.73,-0.4) | -0.82 (-0.99,-0.65) | -1.09 (-1.43,-0.74) |
Oxybutynin IR (2.5-5mg) b.i.d | (24) | -0.53 (-1.14,0.12) | -0.74 (-1.34,-0.09) | -1.05 (-1.72,-0.35) |
Oxybutynin IR 5mg t.i.d | (7) | -0.53 (-0.91,-0.14) | -0.73 (-1.12,-0.34) | -1.07 (-1.55,-0.53) |
Mirabegron 200mg q.d | (53) | -0.52 (-1.11,-0.01) | -0.74 (-1.38,-0.19) | -1.06 (-1.72,-0.43) |
Propiverine IR 15mg b.i.d | (43) | -0.53 (-0.94,-0.1) | -0.71 (-1.15,-0.25) | -1.04 (-1.56,-0.5) |
Oxybutynin vaginal ring 4mg q.d | (16) | -0.51 (-1.12,0.12) | -0.73 (-1.32,-0.1) | -1.04 (-1.66,-0.39) |
Pregabalin 150mg b.i.d | (62) | -0.49 (-1.02,0.06) | -0.74 (-1.24,-0.25) | -1.03 (-1.61,-0.45) |
Tolterodine IR 2mg b.i.d + Pilocarpine 9mg b.i.d | (101) | -0.5 (-0.78,-0.21) | -0.73 (-1.06,-0.41) | -1.03 (-1.47,-0.6) |
Fesoterodine ER 4mg q.d | (25) | -0.49 (-0.67,-0.33) | -0.7 (-0.87,-0.55) | -1.02 (-1.37,-0.68) |
Oxybutynin chloride topical gel 1g q.d | (13) | -0.5 (-0.93,-0.06) | -0.71 (-1.15,-0.28) | -1.03 (-1.54,-0.5) |
Tolterodine ER 4mg q.d | (4) | -0.49 (-0.6,-0.39) | -0.64 (-0.75,-0.52) | -0.98 (-1.28,-0.68) |
Darifenacin ER 15mg q.d | (40) | -0.47 (-0.94,0.03) | -0.68 (-1.18,-0.11) | -1 (-1.55,-0.37) |
Electromagnetic stimulation | (125) | -0.45 (-2.54,1.46) | -0.67 (-2.73,1.22) | -0.98 (-3.1,0.98) |
Oxybutynin gel 84mg/day | (134) | -0.45 (-1.03,0.2) | -0.71 (-1.28,-0.07) | -1.01 (-1.64,-0.25) |
Tolterodine IR 2mg b.i.d | (5) | -0.45 (-0.58,-0.31) | -0.69 (-0.84,-0.53) | -0.97 (-1.3,-0.64) |
Tolterodine IR 2mg b.i.d + PFE | (95) | -0.44 (-1.06,0.22) | -0.65 (-1.29,0.06) | -0.96 (-1.62,-0.23) |
Tolterodine IR 2mg b.i.d + BT | (93) | -0.41 (-0.96,0.11) | -0.67 (-1.23,-0.13) | -0.96 (-1.57,-0.37) |
Propiverine ER 20mg q.d | (41) | -0.41 (-0.59,-0.22) | -0.65 (-0.84,-0.45) | -0.95 (-1.3,-0.59) |
Trospium chloride 45mg t.i.d | (47) | -0.41 (-1.12,0.4) | -0.63 (-1.31,0.13) | -0.94 (-1.69,-0.08) |
Elocalcitol 75mg | (70) | -0.39 (-0.91,0.21) | -0.56 (-1.08,0.07) | -0.9 (-1.53,-0.25) |
Propiverine 45mg t.i.d | (118) | -0.38 (-2.55,1.76) | -0.61 (-2.75,1.58) | -0.93 (-3.13,1.32) |
Fesoterodine ER (4mg-8mg) q.d | (27) | -0.36 (-0.57,-0.13) | -0.64 (-0.84,-0.44) | -0.91 (-1.27,-0.55) |
Tolterodine IR 1mg b.i.d | (6) | -0.34 (-0.67,-0.01) | -0.57 (-0.92,-0.21) | -0.88 (-1.35,-0.42) |
Imidafenacin IR 0.1mg b.i.d | (36) | -0.35 (-0.62,-0.1) | -0.53 (-0.8,-0.28) | -0.86 (-1.26,-0.44) |
Terodiline IR 25mg b.i.d | (28) | -0.35 (-0.81,0.09) | -0.51 (-0.96,-0.09) | -0.86 (-1.37,-0.28) |
Oxybutynin transdermal 3.9mg/day | (10) | -0.32 (-0.64,-0.03) | -0.55 (-0.87,-0.24) | -0.84 (-1.28,-0.44) |
Oxybutynin gel 56mg/day | (135) | -0.32 (-0.95,0.33) | -0.48 (-1.1,0.15) | -0.81 (-1.53,-0.08) |
Oxbutynin patch 73.5mg | (15) | -0.31 (-0.65,0.05) | -0.53 (-0.93,-0.11) | -0.84 (-1.31,-0.34) |
Imidafenacin IR 0.05mg b.i.d | (35) | -0.29 (-0.73,0.17) | -0.53 (-0.99,-0.05) | -0.82 (-1.36,-0.26) |
Darifenacin ER 7.5mg q.d | (39) | -0.28 (-0.85,0.26) | -0.5 (-1.09,0.06) | -0.83 (-1.46,-0.2) |
Elocalcitol 150mg | (69) | -0.28 (-0.82,0.33) | -0.5 (-1.05,0.12) | -0.8 (-1.45,-0.13) |
Duloxetine IR 40mg b.i.d | (65) | -0.27 (-0.77,0.24) | -0.5 (-1.06,0.06) | -0.8 (-1.43,-0.2) |
Solabegron 50mg b.i.d | (54) | -0.24 (-0.52,0.03) | -0.47 (-0.75,-0.21) | -0.77 (-1.18,-0.38) |
Lipo-BoNTA | (138) | -0.21 (-1.06,0.64) | -0.46 (-1.35,0.42) | -0.77 (-1.68,0.19) |
Tarafenacin 0.4mg q.d | (82) | -0.2 (-0.87,0.51) | -0.45 (-1.1,0.27) | -0.74 (-1.45,0.07) |
Serlopitant 0.25mg q.d | (107) | -0.21 (-0.73,0.37) | -0.42 (-0.91,0.09) | -0.72 (-1.36,-0.12) |
Serlopitant 4mg q.d | (109) | -0.19 (-0.76,0.36) | -0.41 (-0.94,0.1) | -0.71 (-1.34,-0.11) |
Pregabalin 75mg b.i.d + Tolterodine ER 2mg q.d | (103) | -0.18 (-0.66,0.3) | -0.42 (-0.9,0.04) | -0.71 (-1.29,-0.17) |
Oxybutynin 20mg intravesically q.d | (106) | -0.15 (-1.63,1.3) | -0.36 (-1.83,1.05) | -0.65 (-2.14,0.75) |
PFMT + BT | (89) | -0.1 (-0.66,0.43) | -0.37 (-0.97,0.2) | -0.66 (-1.28,-0.04) |
Cizolirtine citrate 200mg b.i.d | (56) | -0.12 (-1.5,1.07) | -0.33 (-1.69,0.84) | -0.63 (-2.03,0.52) |
Oxybutynin IR 2.5mg t.i.d | (21) | -0.1 (-0.41,0.21) | -0.42 (-0.9,-0.07) | -0.63 (-1.08,-0.17) |
Percutaneous tibial nerve stimulation | (83) | -0.09 (-1.07,1.21) | -0.35 (-1.32,0.98) | -0.63 (-1.61,0.71) |
Electrostimulation + vaginal oestrogen cream 1.25mg/day | (133) | -0.07 (-0.75,0.63) | -0.23 (-0.9,0.48) | -0.63 (-1.35,0.13) |
Electrostimulation | (80) | -0.03 (-0.48,0.43) | -0.31 (-0.8,0.13) | -0.67 (-1.26,-0.14) |
ONO-8539 100mg b.i.d | (60) | -0.02 (-0.66,0.61) | -0.22 (-0.87,0.41) | -0.53 (-1.23,0.16) |
Oxybutynin ER 15mg q.d | (9) | -0.01 (-1.17,0.83) | -0.22 (-1.41,0.63) | -0.54 (-1.74,0.35) |
Netupitant 200mg q.d | (112) | -0.02 (-1.19,1.09) | -0.23 (-1.42,0.82) | -0.52 (-1.75,0.53) |
Estradiol 25mg | (68) | 0.01 (-0.37,0.37) | -0.21 (-0.67,0.2) | -0.53 (-1.03,-0.02) |
Placebo | (1) | NA | NA | NA |
Netupitant 100mg q.d | (111) | 0.01 (-1.1,0.96) | -0.2 (-1.29,0.71) | -0.52 (-1.62,0.4) |
PFMT | (84) | 0.07 (-0.63,0.64) | -0.18 (-0.85,0.43) | -0.48 (-1.12,0.18) |
Oxybutynin transdermal 1.3mg/day | (11) | 0.07 (-0.46,0.6) | -0.14 (-0.67,0.38) | -0.45 (-1.06,0.11) |
ZD0947IL 25mg/day | (58) | 0.07 (-0.81,0.98) | -0.12 (-1.03,0.82) | -0.45 (-1.39,0.52) |
Serlopitant 1mg q.d | (108) | 0.08 (-0.45,0.66) | -0.14 (-0.64,0.38) | -0.44 (-1.05,0.17) |
Netupitant 50mg q.d | (110) | 0.13 (-1.01,1.11) | -0.1 (-1.19,0.87) | -0.4 (-1.54,0.57) |
Bladder Training | (85) | 0.15 (-0.37,0.66) | -0.07 (-0.58,0.46) | -0.4 (-0.91,0.19) |
Tarafenacin 0.2mg q.d | (90) | 0.15 (-0.55,0.83) | -0.06 (-0.77,0.64) | -0.38 (-1.15,0.38) |
Oxybutynin ER 2.5mg q.d + Bladder training | (92) | 0.22 (-0.83,1.31) | 0 (-1.05,1.11) | -0.32 (-1.34,0.84) |
Oxybutynin transdermal 2.6mg/day | (12) | 0.22 (-0.3,0.74) | -0.03 (-0.55,0.5) | -0.32 (-0.93,0.29) |
Oxybutynin ER (5-30mg) q.d | (22) | 0.23 (-0.34,0.85) | 0.03 (-0.56,0.67) | -0.29 (-0.89,0.38) |
Resiniferatoxin 50nM | (67) | 0.27 (-0.9,1.61) | 0.04 (-1.13,1.36) | -0.26 (-1.48,1.07) |
Vaginal oestrogen cream 1.25mg/day | (132) | 0.29 (-0.24,0.81) | 0.03 (-0.5,0.55) | -0.22 (-0.81,0.41) |
Flavoxate chloride 200mg q.d | (64) | 0.34 (-0.36,1.05) | 0.12 (-0.62,0.88) | -0.2 (-0.95,0.61) |
Oxybutynin IR 5mg b.i.d | (18) | 0.35 (-0.25,0.95) | 0.13 (-0.5,0.75) | -0.17 (-0.88,0.49) |
Emepronium bromide 200mg q.d | (63) | 0.37 (-0.28,1.05) | 0.15 (-0.55,0.87) | -0.16 (-0.9,0.6) |
ONO-8539 300mg b.i.d | (61) | 0.45 (-0.21,1.14) | 0.22 (-0.44,0.91) | -0.1 (-0.78,0.65) |
Propantheline Bromide 15mg t.i.d | (113) | 0.45 (-0.67,2.07) | 0.22 (-0.88,1.89) | -0.09 (-1.26,1.73) |
Oxybutynin ER 2.5mg q.d | (20) | 0.53 (-0.33,1.49) | 0.29 (-0.61,1.25) | -0.01 (-0.9,0.94) |
Estradiol 1mg intravaginally | (127) | 0.58 (-0.74,2.02) | 0.36 (-0.95,1.8) | 0.04 (-1.33,1.52) |
Propiverine 60mg q.d | (119) | 0.59 (-1.97,2.89) | 0.36 (-2.19,2.69) | 0.05 (-2.45,2.45) |
ONO-8539 30mg b.i.d | (59) | 0.56 (-0.04,1.2) | 0.34 (-0.27,0.96) | 0.04 (-0.63,0.75) |
Sham Therapy | (3) | 0.54 (-0.55,2) | 0.35 (-0.75,1.82) | 0.03 (-1.02,1.54) |
Trospium IR 15mg t.i.d | (46) | 0.6 (-0.32,1.46) | 0.43 (-0.49,1.36) | 0.08 (-0.82,1.04) |
Oxybutynin IR (5-20mg) | (23) | 0.68 (-0.66,1.94) | 0.46 (-0.91,1.73) | 0.16 (-1.24,1.46) |
Oxybutynin ER 5-30mg/day + Behaviour therapy | (22) | 0.96 (-0.08,2.17) | 0.72 (-0.3,1.94) | 0.44 (-0.62,1.63) |
Control | (2) | 0.99 (0.22,2.01) | 0.82 (0.04,1.87) | 0.47 (-0.31,1.52) |
Reflexology | (71) | 1.03 (0.25,2.15) | 0.78 (-0.05,1.88) | 0.48 (-0.36,1.61) |
Naftopidil 25mg q.d | (114) | 3.46 (1.53,5.44) | 3.24 (1.29,5.2) | 2.94 (0.95,4.99) |
Solifenacin succinate 5mg q.d + Naftopidil 25mg q.d | (115) | 5.26 (2.92,7.79) | 5.04 (2.71,7.54) | 4.72 (2.43,7.26) |