Table 1 Conditions for each active treatment arm and dose strength. The control arm is modeled separately since standard of care dose not have a known OTU
From: Comparison of hierarchical EMAX and NDLM models in dose-response for early phase clinical trials
Dose index d | Arm Name | OTUs νd∗ 100 | Dose strength νd |
|---|---|---|---|
d = 1 | Control (1.0 ATA) | N/A* | N/A* |
d = 2 | 1.5 ATA | 260 | ν2=2.60 |
d = 3 | 2 ATA | 417 | ν3=4.17 |
d = 4 | NBH (100% FiO2 at 1.0 ATA) | 540 | ν4=5.40 |
d = 5 | 2.5 ATA | 592 | ν5=5.92 |
d = 6 | 1.5 ATA + NBH | 620 | ν6=6.20 |
d = 7 | 2 ATA + NBH | 776 | ν7=7.76 |
d = 8 | 2.5 ATA + NBH | 952 | ν8=9.52 |