Table 2 Three different hypothetical datasets representing different dose-responses
From: Comparison of hierarchical EMAX and NDLM models in dose-response for early phase clinical trials
Dose Strength | d = 1 Control | d = 2 2.60 | d = 3 4.17 | d = 4 5.40 | d = 5 5.92 | d = 6 6.20 | d = 7 7.76 | d = 8 9.52 | |
|---|---|---|---|---|---|---|---|---|---|
n | 39 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | |
Large Monotone | |||||||||
Response | y | 16 | 8 | 10 | 11 | 12 | 14 | 16 | 18 |
%Response | 100*y/n | 41.0% | 34.8% | 43.5% | 47.8% | 52.2% | 60.9% | 69.6% | 78.3% |
NBH Only | |||||||||
Response | y | 16 | 8 | 8 | 18 | 8 | 18 | 18 | 18 |
%Response | 100*y/n | 41.0% | 34.8% | 34.8% | 78.3% | 34.8% | 78.3% | 78.3% | 78.3% |
Over-Dose | |||||||||
Response | y | 16 | 8 | 10 | 12 | 18 | 12 | 4 | 2 |
%Response | 100*y/n | 41.0% | 34.8% | 43.5% | 52.2% | 78.3% | 52.2% | 17.4% | 8.7% |