Table 7 The probability for selecting a correct effective dose (n = 200). All designs are calibrated to have a Type I error rate of 10%
From: Comparison of hierarchical EMAX and NDLM models in dose-response for early phase clinical trials
Hier. EMAX | Simple NDLM | 2nd order NDLM | ||||
|---|---|---|---|---|---|---|
Effect | P(correct) | P(incorrect) | P(correct) | P(incorrect) | P(correct) | P(incorrect) |
Large | 0.946 | 0.000 | 0.946 | 0.000 | 0.878 | 0.000 |
NBH | 0.949 | 0.001 | 0.961 | 0.001 | 0.941 | 0.000 |
overdose | 0.477 | 0.067 | 0.442 | 0.062 | 0.296 | 0.105 |