Table 8 The probability for selecting the maximum effective dose(n = 200). All designs are calibrated to have a Type I error rate of 10%
From: Comparison of hierarchical EMAX and NDLM models in dose-response for early phase clinical trials
Hier. EMAX | Simple NDLM | 2nd order NDLM | ||||
|---|---|---|---|---|---|---|
Effect | P(correct) | P(incorrect) | P(correct) | P(incorrect) | P(correct) | P(incorrect) |
Large | 0.734 | 0.212 | 0.674 | 0.272 | 0.697 | 0.181 |
NBH | 0.949 | 0.001 | 0.961 | 0.001 | 0.941 | 0.000 |
overdose | 0.401 | 0.143 | 0.232 | 0.272 | 0.100 | 0.289 |