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Table 3 Information on comorbidities and prescription medications recorded for the linked sample. Column 1: information recorded in the CHHiP trial at baseline (pre-radiotherapy), Column 2: information in primary care before enrolment to the CHHiP trial and Column 5: information in primary care after enrolment to the CHHiP trial. Date of the trial enrolment was defined as the start date of androgen deprivation therapy. Columns 3 and 4: information not recorded in each of the databases respectively

From: Linkage of the CHHiP randomised controlled trial with primary care data: a study investigating ways of supplementing cancer trials and improving evidence-based practice

  Information recorded at baseline in the CHHiP trial
n (%)
Information recorded in primary care before enrolment to CHHiP
n (%)
Not recoded in the trial
n (%)
Not recorded in primary care
n (%)
Information recorded in primary care after enrolment to CHHiP
n (%)
(new diagnosis)
Past clinical history of comorbidity
 Diabetes 9 (8) 11 (10)
(type1–1, type2–10)
2 (2) 0 12 (11)
(all participants type2)
 Hypertension 38 (36) 40 (38) 14 (13) 12 (11) 9 (8)
 Inflammatory bowel disease 2 (2) Not extracted
 Symptomatic haemorrhoids 5 (5) 5 (5) 5 (5) 5 (5) 14 (13)
Previous pelvic surgery / prostatectomy 8 (7) 14 (13) 11 (10) 5 (5) 3 (3)
Previous transurethral resection of the prostate 16 (15) 52 (49) 38 (36) 2 (2) 3 (3)
Medication
 Alpha-blocker or anticholinergic 12 (11) 9 (8) 8 (7) 11 (10) 16 (15)
 Angiotensin converting enzyme inhibitors Not recorded 22 (20) 22 (21) 15 (14)
 Statins Not recorded 40 (38) 40 (38) 25 (24)
 Metformin Not recorded 7 (7) 7 (7) 7 (7)
 Aspirin Not recorded 32 (30) 32 (30) 12 (11)
 Phosphodiesterase type 5 inhibitors Not recorded 20 (19) 20 (19) 26 (25)
 Rectal steroids Not recorded 7 (7) 7 (7) 17 (16)