Stopping Boundaries for Z Statistics and P-values | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
 | Z at 1st Interim | P at 1st Interim | Z at 1st Futility | P at 1st Futility | Z at 2nd Interim | P at 2nd Interim | Z at 2nd Futility | P at 2nd Futility | Final Z | Final P |
Intermediate Risk Group | ||||||||||
 For Design with 1 Interim Analysis | 2.539 | 0.006 | −0.571 | 0.716 | NA | NA | NA | NA | 1.673 | 0.047 |
 For Design with 2 Interim Analyses | 2.902 | 0.002 | −0.954 | 0.830 | 2.199 | 0.014 | 0.530 | 0.298 | 1.689 | 0.046 |
High Risk Group | ||||||||||
 For Design with 1 Interim Analysis | −2.539 | 0.006 | 0.571 | 0.716 | NA | NA | NA | NA | −1.673 | 0.047 |
 For Design with 2 Interim Analyses | −2.902 | 0.002 | 0.954 | 0.830 | −2.199 | 0.014 | −0.530 | 0.298 | −1.689 | 0.046 |