Skip to main content

Table 11 Stopping Boundaries for Z Statistics and P-values

From: Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

Stopping Boundaries for Z Statistics and P-values
  Z at 1st Interim P at 1st Interim Z at 1st Futility P at 1st Futility Z at 2nd Interim P at 2nd Interim Z at 2nd Futility P at 2nd Futility Final Z Final P
Intermediate Risk Group
 For Design with 1 Interim Analysis 2.539 0.006 −0.571 0.716 NA NA NA NA 1.673 0.047
 For Design with 2 Interim Analyses 2.902 0.002 −0.954 0.830 2.199 0.014 0.530 0.298 1.689 0.046
High Risk Group
 For Design with 1 Interim Analysis −2.539 0.006 0.571 0.716 NA NA NA NA −1.673 0.047
 For Design with 2 Interim Analyses −2.902 0.002 0.954 0.830 −2.199 0.014 −0.530 0.298 −1.689 0.046
  1. All values were calculated based on 90% power