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Table 3 Abbreviated Toxicity Boundaries at Probability of Toxicity = 0.25 and α =0.01

From: Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

Abbreviated Toxicity Boundaries at Probability of Toxicity = 0.25 and α =0.01

Maximum Number of Subjects

Number of Subjects with Toxicities

5

2

6

3

8

4

10

5

12

6

14

7

16

8

18

9

20

10

23

11

25

12

28

13

…

…

52

22

55

23

…

…

79

31

82

32

…

…

107

40

110

41

…

…

158

56

161

57

164

58