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Table 3 Abbreviated Toxicity Boundaries at Probability of Toxicity = 0.25 and α =0.01

From: Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

Abbreviated Toxicity Boundaries at Probability of Toxicity = 0.25 and α =0.01
Maximum Number of Subjects Number of Subjects with Toxicities
5 2
6 3
8 4
10 5
12 6
14 7
16 8
18 9
20 10
23 11
25 12
28 13
52 22
55 23
79 31
82 32
107 40
110 41
158 56
161 57
164 58