Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

Table 7 Full Toxicity Boundaries Table at Probability of Toxicity = 0.25 and α =0.01

Full Toxicity Boundaries Table at Probability of Toxicity = 0.25 and α =0.01
Maximum Number of Subjects	Number of Subjects with Toxicities
5	2
6	3
8	4
10	5
12	6
14	7
16	8
18	9
20	10
23	11
25	12
28	13
30	14
33	15
36	16
38	17
41	18
44	19
47	20
49	21
52	22
55	23
58	24
61	25
64	26
67	27
70	28
73	29
76	30
79	31
82	32
85	33
88	34
91	35
94	36
97	37
100	38
103	39
107	40
110	41
113	42
116	43
119	44
122	45
126	46
129	47
132	48
135	49
138	50
142	51
145	52
148	53
151	54
155	55
158	56
161	57
164	58

ISSN: 1471-2288