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Table 7 Full Toxicity Boundaries Table at Probability of Toxicity = 0.25 and α =0.01

From: Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

Full Toxicity Boundaries Table at Probability of Toxicity = 0.25 and α =0.01
Maximum Number of Subjects Number of Subjects with Toxicities
5 2
6 3
8 4
10 5
12 6
14 7
16 8
18 9
20 10
23 11
25 12
28 13
30 14
33 15
36 16
38 17
41 18
44 19
47 20
49 21
52 22
55 23
58 24
61 25
64 26
67 27
70 28
73 29
76 30
79 31
82 32
85 33
88 34
91 35
94 36
97 37
100 38
103 39
107 40
110 41
113 42
116 43
119 44
122 45
126 46
129 47
132 48
135 49
138 50
142 51
145 52
148 53
151 54
155 55
158 56
161 57
164 58