Handling informative dropout in longitudinal analysis of health-related quality of life: application of three approaches to data from the esophageal cancer clinical trial PRODIGE 5/ACCORD 17

Cuer, B.; Mollevi, C.; Anota, A.; Charton, E.; Juzyna, B.; Conroy, T.; Touraine, C.

doi:10.1186/s12874-020-01104-w

Table 2 Results of the longitudinal analysis of the four dimensions of interest of the EORTC QLQ-C30

From: Handling informative dropout in longitudinal analysis of health-related quality of life: application of three approaches to data from the esophageal cancer clinical trial PRODIGE 5/ACCORD 17

	LMM				SM				PMM				SPM
		Estimate	CI 95%	p		Estimate	CI 95%	p		Estimate	CI 95%	p		Estimate	CI 95%	p
QL (N = 252)
Longitudinal outcome	β₁	0.513	[0.24; 0.78]	<0.001	β₁	0.513	NA	NA	β₁	−0.628	[−1.75; 0.50]	0.275	β₁	0.477	[0.12; 0.84]	0.009
Longitudinal outcome	β₂	−0.130	[− 0.49; 0.23]	0.472	β₂	− 0.130	[− 0.95; 0.69]	0.757	β₂	0.464	[−1.17; 2.10]	0.578	β₂	−0.122	[− 0.48; 0.24]	0.506
Dropout					ψ₀	−0.808	[−1.31; − 0.31]	0.001	\( {\beta}_1^1 \)	−2.611	[−5.59; 0.37]	0.086	γ	−0.042	[− 0.29; 0.21]	0.744
					ψ₁	−0.005	[− 0.01; 0.00]	0.221	\( {\beta}_2^1 \)	1.256	[−3.17; 5.69]	0.579	α	−0.003	[−0.02; 0.02]	0.756
					ψ₂	0.005	[0.00; 0.01]	0.075	\( {\beta}_1^2 \)	−0.649	[−2.02; 0.72]	0.353	ξ₁	0.110	[−3.46; 3.68]	<0.001
									\( {\beta}_2^2 \)	0.722	[−0.96; 2.41]	0.401	ξ₂	0.105	[−3.50; 3.71]	<0.001
									\( {\beta}_1^3 \)	−0.009	[− 0.69; 0.67]	0.980	ξ₃	0.181	[−3.45; 3.81]	0.006
									\( {\beta}_2^3 \)	−0.248	[−1.14; 0.64]	0.586	ξ₄	0.122	[−3.52; 3.77]	0.001
									\( {\beta}_1^4 \)	0.477	[0.15; 0.81]	0.005	ξ₅	0.06	[−3.65; 3.77]	<0.001
									\( {\beta}_2^4 \)	−0.123	[− 0.54; 0.29]	0.559	ξ₆	0.065	[−3.76; 3.89]	<0.001
													ξ₇	0.071	[−4.04; 4.18]	<0.001
PF (N = 254)
Longitudinal outcome	β₁	−0.164	[−0.45; 0.12]	0.266	β₁	1.434	[1.02; 1.85]	<0.001	β₁	−2.652	[−3.67; −1.64]	< 0.001	β₁	−0.394	[− 0.83; 0.04]	0.078
Longitudinal outcome	β₂	−0.112	[− 0.51; 0.29]	0.586	β₂	−0.189	[− 0.68; 0.31]	0.456	β₂	0.300	[−1.10; 1.70]	0.676	β₂	−0.084	[− 0.50; 0.33]	0.691
Dropout					ψ₀	−3.231	[−5.16; −1.30]	0.001	\( {\beta}_1^1 \)	−6.526	[−9.16; − 3.89]	<0.001	γ	− 0.003	[−0.26; 0.25]	0.980
					ψ₁	−0.089	[−0.11; − 0.06]	<0.001	\( {\beta}_2^1 \)	1.135	[−2.86; 5.13]	0.578	α	−0.015	[− 0.03; 0.00]	0.006
					ψ₂	0.107	[0.07; 0.14]	<0.001	\( {\beta}_1^2 \)	−1.805	[−2.98; −0.63]	0.003	ξ₁	0.272	[−2.88; 3.42]	0.006
									\( {\beta}_2^2 \)	0.362	[−1.15; 1.88]	0.640	ξ₂	0.270	[−2.88; 3.42]	0.006
									\( {\beta}_1^3 \)	−0.474	[−1.06; 0.11]	0.115	ξ₃	0.474	[−2.66; 3.61]	0.112
									\( {\beta}_2^3 \)	0.017	[−0.81; 0.84]	0.968	ξ₄	0.309	[−2.82; 3.44]	0.012
									\( {\beta}_1^4 \)	0.152	[−0.16; 0.46]	0.340	ξ₅	0.158	[−2.90; 3.22]	<0.001
									\( {\beta}_2^4 \)	−0.185	[− 0.61; 0.24]	0.391	ξ₆	0.165	[−2.78; 3.12]	< 0.001
													ξ₇	0.185	[−2.94; 3.31]	< 0.001
PA (N = 254)
Longitudinal outcome	β₁	−0.472	[− 0.82; − 0.13]	0.008	β₁	−0.472	[−1.23; 0.29]	0.224	β₁	1.166	[−0.30; 2.63]	0.118	β₁	−0.527	[− 0.99; − 0.07]	0.024
Longitudinal outcome	β₂	0.276	[−0.19; 0.74]	0.242	β₂	0.276	[−0.59; 1.14]	0.531	β₂	−0.501	[−2.60; 1.60]	0.640	β₂	0.285	[−0.18; 0.75]	0.231
Dropout					ψ₀	0	[− 0.20; 0.20]	1	\( {\beta}_1^1 \)	4.582	[0.54; 8.62]	0.027	γ	−0.012	[−0.27; 0.24]	0.927
					ψ₁	0	[−0.01; 0.01]	1	\( {\beta}_2^1 \)	−2.505	[−8.47; 3.46]	0.411	α	−0.003	[−0.02; 0.01]	0.720
					ψ₂	0	[−0.01; 0.01]	1	\( {\beta}_1^2 \)	0.281	[−1.52; 2.08]	0.759	ξ₁	0.086	[−2.49; 2.66]	< 0.001
									\( {\beta}_2^2 \)	0.048	[−2.15; 2.25]	0.966	ξ₂	0.086	[−2.50; 2.67]	<0.001
									\( {\beta}_1^3 \)	0.264	[−0.60; 1.13]	0.551	ξ₃	0.152	[−2.41; 2.72]	<0.001
									\( {\beta}_2^3 \)	0.239	[−0.93; 1.41]	0.689	ξ₄	0.098	[−2.44; 2.63]	<0.001
									\( {\beta}_1^4 \)	−0.511	[−0.93; − 0.09]	0.017	ξ₅	0.053	[−2.42; 2.52]	< 0.001
									\( {\beta}_2^4 \)	0.267	[−0.27; 0.80]	0.328	ξ₆	0.055	[−2.31; 2.43]	<0.001
													ξ₇	0.058	[−2.41; 2.52]	< 0.001
FA (N = 254)
Longitudinal outcome	β₁	−0.514	[−0.86; −0.17]	0.003	β₁	−2.484	[−3.12; −1.84]	<0.001	β₁	3.157	[1.67; 4.65]	<0.001	β₁	−0.399	[−0.86; 0.06]	0.089
Longitudinal outcome	β₂	0.275	[−0.18; 0.73]	0.239	β₂	0.027	[−0.59; 0.64]	0.932	β₂	−0.098	[−2.15; 1.95]	0.926	β₂	0.249	[−0.21; 0.71]	0.288
Dropout					ψ₀	−0.907	[−1.27; − 0.54]	<0.001	\( {\beta}_1^1 \)	8.574	[4.67; 12.48]	<0.001	γ	−0.019	[−0.27; 0.23]	0.883
					ψ₁	0.047	[0.03; 0.06]	<0.001	\( {\beta}_2^1 \)	−0.436	[−6.28; 5.41]	0.884	α	0.006	[−0.01; 0.02]	0.299
					ψ₂	−0.097	[− 0.12; − 0.07]	<0.001	\( {\beta}_1^2 \)	3.118	[1.39; 4.85]	<0.001	ξ₁	0.068	[−2.52; 2.66]	<0.001
									\( {\beta}_2^2 \)	−1.12	[−3.29; 1.05]	0.312	ξ₂	0.064	[−2.55; 2.68]	<0.001
									\( {\beta}_1^3 \)	0.626	[−0.20; 1.45]	0.139	ξ₃	0.117	[−2.48; 2.71]	<0.001
									\( {\beta}_2^3 \)	−0.087	[−1.21; 1.04]	0.880	ξ₄	0.076	[−2.49; 2.64]	<0.001
									\( {\beta}_1^4 \)	−0.737	[−1.14; − 0.34]	<0.001	ξ₅	0.041	[−2.48; 2.56]	<0.001
									\( {\beta}_2^4 \)	0.382	[−0.14; 0.90]	0.149	ξ₆	0.045	[−2.39; 2.48]	<0.001
													ξ₇	0.049	[−2.48; 2.58]	<0.001

Legend: LMM Linear Mixed Model, SM Selection Model, PMM Pattern-Mixture Model, SPM Shared-Parameter Model, CI Confidence Interval, QL Global Health Status, PF Physical functioning, PA Pain, FA Fatigue

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