TY - JOUR AU - Heinecke, Andreas AU - Tallarita, Marta AU - De Iorio, Maria PY - 2020 DA - 2020/10/20 TI - Bayesian splines versus fractional polynomials in network meta-analysis JO - BMC Medical Research Methodology SP - 261 VL - 20 IS - 1 AB - Network meta-analysis (NMA) provides a powerful tool for the simultaneous evaluation of multiple treatments by combining evidence from different studies, allowing for direct and indirect comparisons between treatments. In recent years, NMA is becoming increasingly popular in the medical literature and underlying statistical methodologies are evolving both in the frequentist and Bayesian framework. Traditional NMA models are often based on the comparison of two treatment arms per study. These individual studies may measure outcomes at multiple time points that are not necessarily homogeneous across studies. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-020-01113-9 DO - 10.1186/s12874-020-01113-9 ID - Heinecke2020 ER -