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Table 1 Parameters used in the simulation of the A and B arms

From: Performance of unanchored matching-adjusted indirect comparison (MAIC) for the evidence synthesis of single-arm trials with time-to-event outcomes

 

A arm

B arm

Sample size

1000

800

Mean age

53

56

Standard deviation of age

11

12

Range of age

[21, 80]

[23, 85]

Menopausal status (% post-menopausal)

40

50

tumor grade = 1 (%)

20

10

tumor grade = 2 (%)

65

70

tumor grade = 3 (%)

15

20

Distribution

Weibull

Weibull

Scale parameter

0.00000004

0.00000004

Shape parameter

2.2

2.2

Coefficients of variables (logHR)

  

Age (yearly increment)

0.02

0.02

Menopausal status

0.5

0.5

Indicator variable for tumor grade = 2

0.3

0.3

Indicator variable for tumor grade = 3

0.6

0.6

B indicator

NA

−0.5 (in the scenario without effect modifier) / -0.4 (in the scenario with effect modifier)

B indicator × menopausal status interaction

NA

−0.2 (only applicable to the scenario with effect modifier)

Maximum follow-up time (days)

2500

2500

  1. Abbreviation: HR Hazard ratio; NA Not applicable