Performance of unanchored matching-adjusted indirect comparison (MAIC) for the evidence synthesis of single-arm trials with time-to-event outcomes

Table 5 Estimates of log hazard ratio in scenario 2 (with an effect modifier)

Statistical properties	Unweighted estimate	Weighted estimate
		All variables included in weight	Omitted the effect modifier (menopausal status) from weight	Omitted the effect modifier (menopausal status) and tumor grade from weight
Bias	0.173	0.035	0.079	0.122
MCV	0.002	0.003	0.003	0.002
MSE	0.032	0.004	0.009	0.017
CI coverage (%)	7.7	89.9	68.7	34.1
mean ESS	NA	791	827	888

Abbreviation: MCV Monte-Carlo variance; MSE Mean squared error; CI 95% Confidence interval; ESS Effective sample size

ISSN: 1471-2288