TY - JOUR AU - Nury, E. AU - Bischoff, K. AU - Wollmann, K. AU - Nitschke, K. AU - Lohner, S. AU - Schumacher, M. AU - Rücker, G. AU - Blümle, A. PY - 2020 DA - 2020/10/02 TI - Impact of investigator initiated trials and industry sponsored trials on medical practice (IMPACT): rationale and study design JO - BMC Medical Research Methodology SP - 246 VL - 20 IS - 1 AB - The German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) initiated large research programs to foster high quality clinical research in the academic area. These investigator initiated trials (IITs) cover important areas of medical research and often go beyond the scope of industry sponsored trials (ISTs). The purpose of this project was to understand to what extent results of randomized controlled IITs and ISTs have an impact on medical practice, measured by their availability for decisions in healthcare and their implementation in clinical practice. We aimed to determine study characteristics influencing a trial’s impact such as type of sponsor and place of conduct. In this article, we describe the rationale and design of this project and present the characteristics of the trials included in our study cohort. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-020-01125-5 DO - 10.1186/s12874-020-01125-5 ID - Nury2020 ER -