BMC Medical Research Methodology

Table 1 Study cohort. For search strategies, please refer to Additional file 1

From: Impact of investigator initiated trials and industry sponsored trials on medical practice (IMPACT): rationale and study design

	Sub-cohort	Source	Number of trials
IITs	Public Germany		120
	Public Germany gov	DFG/GEPRIS (n = 27), BMBF website (n = 33)	60
	Public Germany other	DRKS (n = 47), ClinicalTrials.gov (n = 13)	60
	Public International	ClinicalTrials.gov	200
ISTs	Commercial Germany^a	DRKS (n = 42), ClinicalTrials.gov (n = 158)	171
ISTs	Commercial International	ClinicalTrials.gov	200

^a Due to an insufficient number of non-drug ISTs in the registries searched, we could only include 171 trials in the sub-cohort Commercial Germany (please refer to section “Balancing process” and Table 3)

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