Table 1 Search strategy for the study

1

((heterogen$ and effect$) or (effect and modif$)).tw.

2

regression.tw.

3

treatment$.tw.

4

(treatment adj1 effect$).tw.

5

(treatment adj1 difference$).tw.

6

exp risk/ or risk.tw.

7

3 or 4 or 5 or 6

8

*Models, Statistical/

9

*Randomized Controlled Trials as Topic/mt

10

Multicenter Studies as Topic/mt

11

*Randomized Controlled Trials as Topic/sn

12

Multicenter Studies as Topic/sn

13

*Clinical Trials as Topic/sn

14

*Precision Medicine/mt

15

or/8–14

16

1 and 2

17

2 and 7

18

15 and 17

19

15 and 16

20

18 or 19