Table 1 Baseline variables in development and validation cohorts

N

1,497,511

393,071

1,555,010

410,068

Age

43.07 (14.84)

37.18 (12.42)

44.56 (16.22)

37.4 (13.41)

BMI

26.07 (4.43)

26.3 (4.8)

25.54 (5.47)

25.78 (5.96)

Cholesterol/HDL ratio

4.51 (1.4)

4.32 (1.37)

3.76 (1.21)

3.52 (1.1)

SBP

130.67 (17.04)

127.71 (14.07)

125.15 (19.04)

119.53 (14.43)

SBP variability

10.37 (6.92)

9.39 (6.37)

9.66 (6.21)

8.87 (5.17)

Atrial fibrillation

0.61%

0.44%

0.48%

0.28%

Atypical anti-psychotic medication

0.25%

0.62%

0.23%

0.58%

Corticosteroid use

0.31%

0.22%

0.51%

0.36%

CKD stage 3/4/5

0.25%

0.57%

0.33%

0.95%

Diabetes (type 1)

0.26%

0.36%

0.19%

0.27%

Diabetes (type 2)

1.56%

0.93%

1.26%

0.78%

Ethnicity = Asian other

1.56%

2.84%

1.49%

2.88%

Bangladesh

0.34%

0.79%

0.24%

0.48%

Black

2.93%

5.80%

3.12%

5.90%

Chinese

0.45%

0.87%

0.56%

1.17%

Indian

2.49%

4.18%

2.21%

3.63%

Mixed

0.69%

1.47%

0.75%

1.64%

Other

1.53%

2.72%

1.45%

2.84%

Pakistan

0.92%

1.94%

0.76%

1.64%

White

89.09%

79.39%

89.42%

79.81%

Family history of CHD

10.67%

12.36%

14.89%

15.80%

HIV/AIDS

0.06%

0.19%

0.04%

0.13%

Migraine

2.71%

3.85%

6.73%

9.30%

Rheumatoid arthritis

0.28%

0.17%

0.74%

0.47%

Severe mental illness

4.59%

4.55%

9.07%

6.95%

SLE

0.01%

0.01%

0.09%

0.11%

Smoking = Never

47.37%

44.77%

57.03%

53.30%

Smoking = Ex

16.09%

20.59%

14.97%

22.49%

Smoking = Yes

36.53%

34.63%

28.00%

24.21%

Townsend = 1 (least deprived)

22.79%

17.30%

23.08%

17.70%

Townsend = 2

22.32%

18.38%

22.76%

19.03%

Townsend = 3

20.77%

20.82%

21.19%

21.17%

Townsend = 4

20.23%

22.85%

19.91%

22.53%

Townsend = 5

13.89%

20.65%

13.06%

19.57%

Treated hypertension

4.82%

3.28%

6.81%

3.81%