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Table 1 Baseline variables in development and validation cohorts

From: An assessment of the potential miscalibration of cardiovascular disease risk predictions caused by a secular trend in cardiovascular disease in England

  Male development Male validation Female development Female validation
N 1,497,511 393,071 1,555,010 410,068
Age 43.07 (14.84) 37.18 (12.42) 44.56 (16.22) 37.4 (13.41)
BMI 26.07 (4.43) 26.3 (4.8) 25.54 (5.47) 25.78 (5.96)
Cholesterol/HDL ratio 4.51 (1.4) 4.32 (1.37) 3.76 (1.21) 3.52 (1.1)
SBP 130.67 (17.04) 127.71 (14.07) 125.15 (19.04) 119.53 (14.43)
SBP variability 10.37 (6.92) 9.39 (6.37) 9.66 (6.21) 8.87 (5.17)
Atrial fibrillation 0.61% 0.44% 0.48% 0.28%
Atypical anti-psychotic medication 0.25% 0.62% 0.23% 0.58%
Corticosteroid use 0.31% 0.22% 0.51% 0.36%
CKD stage 3/4/5 0.25% 0.57% 0.33% 0.95%
Diabetes (type 1) 0.26% 0.36% 0.19% 0.27%
Diabetes (type 2) 1.56% 0.93% 1.26% 0.78%
Ethnicity = Asian other 1.56% 2.84% 1.49% 2.88%
Bangladesh 0.34% 0.79% 0.24% 0.48%
Black 2.93% 5.80% 3.12% 5.90%
Chinese 0.45% 0.87% 0.56% 1.17%
Indian 2.49% 4.18% 2.21% 3.63%
Mixed 0.69% 1.47% 0.75% 1.64%
Other 1.53% 2.72% 1.45% 2.84%
Pakistan 0.92% 1.94% 0.76% 1.64%
White 89.09% 79.39% 89.42% 79.81%
Family history of CHD 10.67% 12.36% 14.89% 15.80%
HIV/AIDS 0.06% 0.19% 0.04% 0.13%
Migraine 2.71% 3.85% 6.73% 9.30%
Rheumatoid arthritis 0.28% 0.17% 0.74% 0.47%
Severe mental illness 4.59% 4.55% 9.07% 6.95%
SLE 0.01% 0.01% 0.09% 0.11%
Smoking = Never 47.37% 44.77% 57.03% 53.30%
Smoking = Ex 16.09% 20.59% 14.97% 22.49%
Smoking = Yes 36.53% 34.63% 28.00% 24.21%
Townsend = 1 (least deprived) 22.79% 17.30% 23.08% 17.70%
Townsend = 2 22.32% 18.38% 22.76% 19.03%
Townsend = 3 20.77% 20.82% 21.19% 21.17%
Townsend = 4 20.23% 22.85% 19.91% 22.53%
Townsend = 5 13.89% 20.65% 13.06% 19.57%
Treated hypertension 4.82% 3.28% 6.81% 3.81%
  1. Mean (sd) is given of continuous variables, and proportions for categorical variables. BMI body mass index, CKD chronic kidney disease, HDL high-density lipoprotein, SBP systolic blood pressure, SLE systemic lupus erythematosus