Table 2 Parameter estimates and standard errors of multivariate joint modelling of Triglycerides (TG) with CHD, High density lipoprotein (HDL) with CHD, high-sensitivity C-reactive protein (hsCRP) with CHD, and Total cholesterol (TC) with CHD
From: Joint modelling of longitudinal lipids and time to coronary heart disease in the Jackson Heart Study
| Â | Â | TG | HDL | hsCRP | TC |
|---|---|---|---|---|---|
Effect | Parameter | Estimate(SE) | Estimate(SE) | Estimate(SE) | Estimate(SE) |
Longitudinal | |||||
Intercept | β0 | 3.7360 (0.0501) | 4.1408 (0.0276) | -3.7758 (0.1158) | 5.1797 (0.0194) |
Age | β1 | 0.0054 (0.0006) | 0.0022 (0.0003) | 0.0058 (0.0003) | 0.0025 (0.0003) |
Men | β2 | 0.1343 (0.0155) | -0.2002 (0.0077) | -0.3700 (0.0322) | -0.0272 (0.0062) |
Diabetes | β3 | 0.1018 (0.0140) | -0.0378 (0.0064) | 0.0537 (0.0281) | -0.0172 (0.0059) |
Hypertension | β4 | 0.0663 (0.0113) | 0.0057 (0.0051) | 0.1077 (0.0246) | 0.0128 (0.0047) |
Time | β5 | -0.0047 (0.0010) | 0.0138 (0.0004) | 0.0226 (0.0023) | 0.0028 (0.0004) |
BMI | β6 | 0.0115 (0.0010) | -0.0085 (0.0006) | 0.0666 (0.0024) | -0.0005 (0.0004) |
Statin | β7 | -0.0952 (0.0118) | 0.0131 (0.0052) | -0.2588 (0.0258) | -0.1427 (0.0057) |
Smoking | β8 | 0.1569 (0.0238) | -0.0209 (0.0118) | 0.3624 (0.0530) | -0.0153 (0.0095) |
Std dev. error | σ | 0.2812 (0.0037) | 0.1200 (0.0017) | 0.6229 (0.0129) | 0.1206 (0.0018) |
Survival | |||||
Intercept | ξ0 | 9.5160 (0.5302) | 9.4283 (0.5296) | 9.4111 (0.5241) | 9.3920 (0.5116) |
Age | ξ1 | -0.0542 (0.0063) | -0.0525 (0.0063) | -0.0528 (0.0063) | -0.0530 (0.0063) |
Men | ξ2 | -0.4067 (0.1439) | -0.3893 (0.1439) | -0.3568 (0.1439) | -0.3820 (0.1416) |
Diabetes | ξ3 | -0.7477 (0.1396) | -0.7493 (0.1394) | -0.7683 (0.1397) | -0.7583 (0.1399) |
Hypertension | ξ4 | -0.9204 (0.1922) | -0.9219 (0.1911) | -0.9100 (0.1911) | -0.9415 (0.1917) |
BMI | ξ5 | 0.0082 (0.0112) | 0.0081 (0.0112) | 0.0086 (0.0109) | 0.0098 (0.0108) |
Statin | ξ6 | -0.3312 (0.1557) | -0.3830 (0.1530) | -0.3844 (0.1527) | -0.3360 (0.1563) |
Smoking | ξ7 | -0.7003 (0.1807) | -0.7022 (0.1792) | -0.6941 (0.1812) | -0.7026 (0.1815) |
Std dev. RE | d | 0.4061 (0.0070) | 0.2153 (0.0029) | 0.8643 (0.0141) | 0.1598 (0.0027) |
Assoc. | θ | -0.4473 (0.1705) | 1.0472 (0.3404) | -0.2504 (0.0884) | -0.7682 (0.5354) |
Correlation | |||||
TG | Â | 1 | -0.5026 (0.0159) | 0.1478 (0.0190) | 0.4390 (0.0185) |
HDL | Â | Â | 1 | -0.1112 (0.0195) | 0.2235 (0.0194) |
hsCRP | Â | Â | Â | 1 | 0.0268 (0.0215) |
TC | Â | Â | Â | Â | 1 |