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Table 2 Regression coefficients estimates and predictive performance measures for the GUSTO-I trial Westen dataset

From: Re-evaluation of the comparative effectiveness of bootstrap-based optimism correction methods in the development of multivariable clinical prediction models

 

8-Predictor Model

17-Predictor Model

ML

Firth

Ridge

Lasso

Elastic-net

Backward

(AIC)

Backward

(P <  0.05)

ML

Firth

Ridge

Lasso

Elastic-net

Backward

(AIC)

Backward

(P <  0.05)

Coefficients:

 Intercept

−5.092

−5.034

−4.787

−4.933

− 4.886

− 4.927

− 4.927

−5.090

−4.983

−3.434

−3.494

−3.486

−3.494

−2.853

 Age > 65 years

1.637

1.616

1.424

1.578

1.535

1.631

1.631

1.429

1.399

1.161

1.336

1.324

1.495

1.532

 Female gender

0.622

0.620

0.592

0.586

0.586

0.624

0.624

0.490

0.487

0.380

0.288

0.289

0.368

.

 Diabetes

0.069

0.083

0.078

0.024

0.035

.

.

0.153

0.164

0.131

.

.

.

.

 Hypotension

1.218

1.215

1.102

1.164

1.145

1.252

1.252

1.192

1.178

1.037

1.036

1.030

1.230

1.227

 Tachycardia

0.650

0.645

0.574

0.608

0.597

0.661

0.661

0.653

0.643

0.533

0.530

0.526

0.669

0.717

 High risk

0.847

0.835

0.748

0.796

0.781

0.855

0.855

0.403

0.397

0.390

0.372

0.372

0.414

2.748

 Shock

2.395

2.362

2.339

2.362

2.354

2.424

2.424

2.685

2.608

2.508

2.460

2.455

2.662

0.779

 No relief of chest pain

0.263

0.255

0.237

0.219

0.221

.

.

0.233

0.223

0.200

0.107

0.107

.

.

 Previous MI

       

0.505

0.495

0.437

0.378

0.376

0.586

.

 Height

       

0.008

0.008

−0.001

.

.

.

.

 Weight

       

−0.019

−0.018

−0.015

−0.014

−0.014

−0.018

−0.023

 Hypertension history

       

−0.165

−0.159

−0.123

.

.

.

.

 Ex-smoker

       

0.174

0.169

0.147

.

.

.

.

 Current smoker

       

0.247

0.241

0.231

0.057

0.059

.

.

 Hypercholesterolemia

       

−0.064

−0.060

−0.064

.

.

.

.

 Previous angina pectoris

       

0.246

0.243

0.235

0.151

0.151

.

.

 Family history of MI

       

−0.015

−0.014

−0.036

.

.

.

.

 ST elevation in > 4 leads

       

0.583

0.571

0.479

0.434

0.430

0.601

0.752

C-statistics:

 Apparent

0.819

0.819

0.819

0.819

0.819

0.820

0.820

0.832

0.832

0.831

0.831

0.831

0.829

0.824

 Harrell

0.810

0.810

0.812

0.810

0.810

0.811

0.810

0.811

0.811

0.812

0.812

0.812

0.810

0.806

 .632

0.811

0.811

0.812

0.811

0.810

0.811

0.809

0.811

0.811

0.813

0.813

0.813

0.809

0.808

 .632+

0.810

0.811

0.812

0.811

0.810

0.811

0.809

0.810

0.810

0.812

0.812

0.812

0.809

0.808