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Table 3 results of the Theorical Blood Concentration (TBC) and the Weighted Cumulative Exposure (WCE) models (PRODIGE 9 reanalysis; n=382)

From: Impact of time-varying cumulative bevacizumab exposures on survival: re-analysis of data from randomized clinical trial in patients with metastatic colo-rectal cancer

 

TG + TBC [4]

TG + WCE [5]

 

Model 5

HR [95%-CI]

Model 6 (120 days)

HR [95%-CI]

Control (ref.)

1

1

Maintenance group

1.31 [1.03–1.66]

1.23 [0.95–1.58]

Theorical Blood Concentration (1 mg/kg)

0.77 [0.72–0.82]

 

Weighted cumulative exposure

 

Figure 2B

AIC

2096.3

2102.0

Global Grambsch test

0.44

0.06

  1. AIC Akaike Information Criterion, CI Confidence Interval