TY - JOUR AU - Spineli, Loukia M. AU - Papadimitropoulou, Katerina AU - Kalyvas, Chrysostomos PY - 2021 DA - 2021/01/07 TI - Pattern-mixture model in network meta-analysis of binary missing outcome data: one-stage or two-stage approach? JO - BMC Medical Research Methodology SP - 12 VL - 21 IS - 1 AB - Trials with binary outcomes can be synthesised using within-trial exact likelihood or approximate normal likelihood in one-stage or two-stage approaches, respectively. The performance of the one-stage and the two-stage approaches has been documented extensively in the literature. However, little is known about how these approaches behave in the presence of missing outcome data (MOD), which are ubiquitous in clinical trials. In this work, we compare the one-stage versus two-stage approach via a pattern-mixture model in the network meta-analysis using Bayesian methods to handle MOD appropriately. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-020-01205-6 DO - 10.1186/s12874-020-01205-6 ID - Spineli2021 ER -