From: A systematic survey of randomised trials that stopped early for reasons of futility
Characteristics | N | |
---|---|---|
Who made decision to stop early | Investigators on advice from DSMB / DSMB / Sponsor / Executive committee / Not stated | 30 / 3 / 3 / 1 / 15 |
Actual information % at last IA | < 40 / 40–59 / 60–79 / 80+ / Not stated or unclear | 11 / 20 / 12 / 6 / 3 |
Basis for stoppinga | Continuation would not change results Futility mentioned Lack of treatment effect Conditional power Prior guidelines / boundary or threshold crossed “unlikely to become statistically significant”, or similar statement. Other | 3 23 20 3 9 9 8 |
How futility was described | Futility claimed, no details Futility analysis described, but CP not reported CP reported in detail Not stated or unclear | 35 4 11 2 |
Conditional power evaluation | Reported by authors / Calculated by us / Impossible to calculate | 11 / 25 / 16 |
Analyses after last IA | Yes / No / Unclear or not applicable | 21 / 23 / 6 / 2 |