Fig. 2

Comparing drug use in children and adults aligned by diagnosis. a. The heatmap on the top section shows the clustering of the diagnoses. The first row of the heatmap shows the 3205 diagnoses used in the children’s hospital. The red section contains 1137 unique diagnoses only used in the children’s hospital. The other 2068 diagnoses shown in green are also used in the general hospital. The other three rows of the heatmap show, from top to bottom, the percentage of associated drugs in the children’s hospital, the general hospital, and their overlap. The mirror histograms in the middle show the incidences of these diagnoses in the children’s hospital (blue) and the general hospital (brown). The bottom mirror histograms show the number of associated drugs in the children’s hospital (blue), the general hospital (brown) and their overlap (red). Based on the clustering, the disease spectrum in the children’s hospital can be classified into groups A-G (7 groups). b. The heatmap shows the percentages of ICD-10 categories belonging to the 7 (A-G) groups generated in Fig. 2a