Framework for personalized prediction of treatment response in relapsing remitting multiple sclerosis

Table 4 Most important predictors in the relapse model

Rank^a	Predictor	Sign^b	MAD
1	Current = TERI: Current duration	–	4.301
2	Intercept	–	0.553
3	Current = TERI	–	1.406
4	Current = FTY: Current duration	+	1.983
5	Index = NA: Diagnosis distance	+	0.368
6	Current duration	+	1.414
7	Index = TERI: Relapses count	–	0.332
8	Index = FTY: Second-line = TRUE	–	0.335

MAD median absolute deviation, TERI Teriflunomide, FTY Fingolimod, NA Natalizumab, Second-line DMT to be employed by label of the European Medical Agency if previous DMT failed to achieve sufficient control of disease activity.
^a Ranked according to the magnitude of the median of the corresponding coefficient’s posterior distribution
^b A positive sign is associated with a boosting effect on the number of relapses; a negative sign is associated with a lessening effect on the number of relapses

ISSN: 1471-2288