Framework for personalized prediction of treatment response in relapsing remitting multiple sclerosis

Table 5 Most important predictors in the CDP model

Rank^a	Predictor	Sign^b	MAD
1	Intercept	–	0.721
2	Index = TERI: Second-line = TRUE	–	0.977
3	Index = NA: Second-line = TRUE	–	0.837
4	Index = NA: Diagnosis distance	+	0.518
5	Index = FTY: Second-line = TRUE	–	0.487
6	Current = IF: Current duration	–	1.604
7	Current = NA: Current duration	–	2.124
8	Current	+	0.711

MAD median absolute deviation, TERI Teriflunomide, FTY Fingolimod, NA Natalizumab, IF Interferon-ß1, Second-line DMT to be employed by label of the European Medical Agency if previous DMT failed to achieve sufficient control of disease activity.
^a Ranked according to the magnitude of the median of the corresponding coefficient’s posterior distribution
^b A positive sign is associated with a boosting effect on the likelihood of observing a CDP; a negative sign is associated with a lessening effect on the likelihood of observing a CDP

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