Measure | Out-of-samplea mean | In-sampleb mean | Sample sizec | Response | Model |
---|
C-Index | 0.579 | 0.652 | 307,784 | CDP | predictive |
C-Index | 0.646 | 0.675 | 505,724 | Relapse | predictive |
MSE | 0.125 | 0.119 | 3119 | CDP | predictive |
MSE | 0.748 | 0.711 | 3119 | Relapse | predictive |
NLL | 1254.330 | 1192.544 | 3119 | CDP | predictive |
NLL | 2581.261 | 2523.731 | 3119 | Relapse | predictive |
- CDP confirmed disability progression, C-Index Harrell’s concordance statistic, MSE mean squared error, NLL negative log-likelihood.
- a Based on predictions for patients from a clinical site not used during training
- b Based on predictions for all patients from all clinical sites used for training
- c Refers either to the number of observations (MSE, NLL) or the number of matched pairs (C-Index)