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Table 2 GRADE assessment of the included studies

From: A systematic review of methodology used in the development of prediction models for future asthma exacerbation

Number of studiesCertainty assessmentCertaintyImportance
Study designRisk of biasInconsistencyIndirectnessImprecisionOther considerations
Exacerbation
 5Observational studiesNot seriousNot seriousNot seriousNot seriousNone
HIGH
CRITICAL
Risk (Categorical)
 2Observational studiesNot seriousNot seriousNot seriousNot seriousNone
LOW
CRITICAL
Time to first severe exacerbation
 1Observational studiesNot seriousNot seriousNot seriousNot seriousPublication bias strongly suspected dose response curvea
HIGH
CRITICAL
Asthma admissions
 1Observational studiesNot seriousNot seriousNot seriousNot seriousNone
HIGH
IMPORTANT
Relapse
 1Observational studiesNot seriousNot seriousNot seriousNot seriousNone
HIGH
IMPORTANT
  1. aContributions from pharmaceutical company employees