From: A scoping review of studies using observational data to optimise dynamic treatment regimens
 | Clinical focus |  | |
---|---|---|---|
Characteristic | No | Yes | Overall |
Publications (n) | 45 | 18 | 63 |
Year published (%) | |||
 1995 to 1999 | 1 (2) | 0 (0) | 1 (2) |
 2000 to 2004 | 2 (4) | 0 (0) | 2 (3) |
 2005 to 2009 | 6 (13) | 3 (17) | 9 (14) |
 2010 to 2014 | 12 (27) | 6 (33) | 18 (29) |
 2015 to 2019 | 18 (40) | 7 (39) | 25 (40) |
 2020 | 6 (13) | 2 (11) | 8 (13) |
Clinical area (%) | |||
 Cancer | 7 (16) | 1 (6) | 8 (13) |
 Diabetes | 6 (13) | 0 (0) | 6 (10) |
 HIV/AIDS | 15 (33) | 12 (67) | 27 (43) |
 Other | 14 (31) | 5 (28) | 19 (30) |
 Thrombosis | 3 (7) | 0 (0) | 3 (5) |
Outcome type (%) | |||
 Binary | 4 (9) | 3 (17) | 7 (11) |
 Categorical | 1 (2) | 0 (0) | 1 (2) |
 Continuous | 17 (38) | 2 (11) | 19 (30) |
 Time-to-event | 23 (51) | 13 (72) | 36 (57) |
Participants (median [IQR]) | 2604 [710, 13,039] | 9793 [3084, 39,887] | 3882 [1420, 23,602] |
Funding source/s (%) | |||
 Non-profit | 4 (9) | 2 (11) | 6 (10) |
 Not reported | 9 (20) | 1 (6) | 10 (16) |
 Public | 35 (78) | 16 (89) | 51 (81) |
Statistical method/s (%) | |||
 G-estimation | 4 (9) | 0 (0) | 4 (6) |
 Inverse probability weighting | 17 (38) | 9 (50) | 26 (41) |
 Other | 9 (20) | 1 (6) | 10 (16) |
 Parametric G-formula | 8 (18) | 8 (44) | 16 (25) |
 Q-learning | 9 (20) | 1 (6) | 10 (16) |
 Regret regression | 3 (7) | 0 (0) | 3 (5) |
 TMLE | 4 (9) | 0 (0) | 4 (6) |
Missing data addressed (%) | 24 (53) | 8 (44) | 32 (51) |
Model evaluation included (%) | 22 (49) | 8 (44) | 30 (48) |
Model selection included (%) | 19 (42) | 15 (83) | 34 (54) |
Sensitivity analysis included (%) | 23 (51) | 15 (83) | 38 (60) |
Software included (%) | |||
 No | 25 (56) | 17 (94) | 42 (67) |
 R | 18 (40) | 0 (0) | 18 (29) |
 SAS | 2 (4) | 1 (6) | 3 (5) |